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CD4 cytotoxic T lymphocyte differentiation
Biochimie, 1988In vitro allostimulated CD4+ human lymphocytes were cloned by micromanipulation and expanded for a short time in IL-2 conditioned medium. In the present study we observed that proliferative noncytotoxic cloned cells were able to acquire the specific cytolytic activity under some modification of the cloned cells restimulation cycle. We demonstrated that
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Cytotoxic T-Lymphocyte-, and Helper T-Lymphocyte-Oriented DNA Vaccination
DNA and Cell Biology, 2004DNA vaccines have advantages over other types of vaccines in that they can induce strong cellular immune responses, namely cytotoxic T lymphocytes (CTL) and helper T lymphocytes (Th). DNA vaccines are therefore considered a promising alternative to attenuated live vaccines in the field of infectious diseases.
Toshi, Nagata +4 more
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Allogeneic tumor-specific cytotoxic T lymphocytes
Cancer Immunology Immunotherapy, 1992We report the development of cytotoxic T lymphocytes specific for an allogeneic brain tumor in a rat model. DA strain cytotoxic T cell precursors stimulated by an allogeneic tumor (9L gliosarcoma) from the Fischer rat could generate a population of cytotoxic T lymphocytes that lysed the allogeneic 9L tumor but failed to lyse other targets, including ...
J M, Redd +3 more
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Killing Mechanisms of Cytotoxic T Lymphocytes
Physiology, 1998Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.
Peter, Groscurth, Luis, Filgueira
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Cytotoxic T lymphocytes in herpesvirus infections
Veterinary Immunology and Immunopathology, 1984A. INTRODUCTION B. MEASUREMENT OF CTL AND THEIR DIFFERENTIATION FROM OTHER FORMS OF CYTOTOXICITY 1. The chromium re lease assay 2. S p e c i f i c i t y con t ro l s 3. I d e n t i f i c a t i o n of e f f e c t o r c e l l s w i th a l l o a n t i s e r a 4. Ef fec t of i n h i b i t o r s on CTL 5. Target c e l l s C.
B T, Rouse, D W, Horohov
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Virus-Neuron-Cytotoxic T Lymphocyte Interactions
1995Neurons have evolved unique strategies to evade immune recognition which allow viruses to infect and persist, yet resist attack by antiviral cytotoxic T lymphocytes (CTLs). However, the ability of activated CTLs to percolate through the normal central nervous system (CNS) (Hickey et al.
G F, Rall, M B, Oldstone
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Radiosensitivity of Murine T-Lymphocyte Cytotoxicity
Radiation Research, 1984A biphasic curve was observed when surviving allogeneic lytic activity was plotted as a function of irradiation delivered before sensitization. Flow cytometry analysis demonstrated that the number of cells was reduced in response to increasing dose and that subset precursors Lyt 1+2+ were proportionally more radiosensitive than the other subsets ...
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Cytotoxic T-Lymphocyte–Associated Antigen-4
Clinical Cancer Research, 2007Abstract Previously, the development of immune-based therapies has primarily focused on vaccines and cytokines, yielding benefit in a small percentage of patients. Recent advances in our understanding of the function of costimulatory molecules have revitalized enthusiasm in the development of immune therapies for cancer.
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