Results 231 to 240 of about 10,638,486 (296)

The PVR-TIGIT/CD96/CD226 axis: a novel immune checkpoint target in ovarian cancer. [PDF]

Front Immunol
Huang M, Zhang J, Huang H, Liu L, Zou Y.
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Increased Abundance of Cytotoxic T Cells in Synovial Fluid of a Dog With Erosive Immune-Mediated Polyarthritis. [PDF]

Case Rep Vet Med
Murakami K, Kobayashi K, Kutara K, Nakamura SI, Tagawa M, Itoi T.   +5 more
europepmc   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Turning resistance into therapeutic vulnerability: Mechano-reprogramming in cancer. [PDF]

Mechanobiol Med
Qu Y, Wang Y.
europepmc   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Evaluation of extracellular microRNAs as potential biomarker candidates for assessing chlamydia reinfection risk. [PDF]

PLoS One
Lewis CM, Gupta K, Wiener H, Tiwari HK, Geisler WM.   +4 more
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Lipid-driven epigenetic exhaustion: linking palmitate metabolism to CD8⁺ T-cell dysfunction in cancer. [PDF]

Immunometabolism (Cobham)
Raj D, Kathania M, Wu T, Theiss AL, Venuprasad K.   +4 more
europepmc   +1 more source

What Do We Know About Immune System Aging from Human and Animal Studies? [PDF]

Int J Mol Sci
Cąkała-Jakimowicz M, Domaszewska-Szostek A, Puzianowska-Kuźnicka M.   +2 more
europepmc   +1 more source