Results 21 to 30 of about 724,385 (326)

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules [PDF]

, 1991
THE α1 and α2 domains of major histocompatibility complex (MHC) class I molecules function in the binding and presentation of foreign peptides to the T-cell antigen receptor and control both negative and positive selection of the T-cell repertoire ...
AM Norment, Carla J. Aldrich, CJ Aldrich, CJ Aldrich, HR MacDonald, HS Teh, HS Teh, HS Teh, IA Stroynowski, IS Trowbridge, Iwona Stroynowski, J Sprent, James Forman, JC Zuniga-Pflucker, JM Connolly, Lee Hood, M Reddehase, MA Alexander, PJ Bjorkman, R Salter, RC Budd, Robert E. Hammer, RR Zamoyska, S Marusic-Galesic, S Qin, Sharon Jones-Youngblood, UH Koszinowski, Ulrich Koszinowski, W-P Fung-Leung, WR Lie, WR Lie   +30 more
core   +1 more source

Cytotoxic T Lymphocytes in Rasmussen’s Encephalitis

Pediatric Neurology Briefs, 2002
The role of cytotoxic T lymphocytes and other mechanisms in the pathogenesis of Rasmussen’s encephalitis (RE) is reviewed at the University of Vienna, Austria, and the University of Bonn, Germany.
J Gordon Millichap
doaj   +1 more source

Generation of virus-specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus-specific cytotoxic T cells [PDF]

, 1979
H-2-restricted cytotoxic T cells specific for Sendai virus were generated in vitro in a primary response from normal mouse lymphocytes cultured in the presence of infective as well as inactivated Sendai virus. Antigen-presenting cells of different origin,
Andersson, Burakoff, Butchko, Cantor, Cantor, Cerottini, Cerottini, Dunlop, Engers, Engers, Ennis, Ertl, Ertl, Finberg, Gething, Hapel, Hayry, Julius, Jung, Kessel, Kirchner, Koszinowski, Koszinowski, Koszinowski, Lafferty, Levy, Lightbody, McKenzie, Palmer, Parker, Pfitzenmaier, Plate, Röllinghoff, Schrader, Shen, Simon, Wagner, Wagner, Wiktor, Zinkernagel, Zinkernagel, Zweerinck   +41 more
core   +1 more source

Peripheral blood lymphocyte subtypes in dogs with different stages of myxomatous mitral valve disease

Journal of Veterinary Internal Medicine, 2021
Background Data on alterations in peripheral blood lymphocyte (PBL) subtypes in dogs with myxomatous mitral valve disease (MMVD) is lacking. Objectives To investigate PBL subtypes and their correlation with parameters of inflammation and MMVD progression
Natalia Druzhaeva, Alenka Nemec Svete, Alojz Ihan, Katka Pohar, Aleksandra Domanjko Petrič   +4 more
doaj   +1 more source

High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity [PDF]

Frontiers in Immunology, 2021
Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown.
Jie Zhu, Jie Zhu, Wenjuan Yang, Xiangda Zhou, Dorina Zöphel, Leticia Soriano-Baguet, Leticia Soriano-Baguet, Leticia Soriano-Baguet, Denise Dolgener, Christopher Carlein, Chantal Hof, Renping Zhao, Shandong Ye, Eva C. Schwarz, Dirk Brenner, Dirk Brenner, Dirk Brenner, Leticia Prates Roma, Bin Qu, Bin Qu   +19 more
openaire   +5 more sources

Methods and compositions for stimulating T-lymphocytes [PDF]

, 2003
Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A., Ioannides, Constantin G., Ioannides, Maria G.   +2 more
core   +1 more source

Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells [PDF]

, 1975
Vaccinia virus specific cytotoxicity against infected target cells was observed in vitro. Spleen lymphocytes from normal and immunized mice of the inbred strains C3H and DBA/2 were incubated with vaccinia virus-infected and non-infected 51Cr-labeled ...
Alkan, Boyum, Brunner, Calder, Cohen, Epstein, Evans, Fulginiti, Gardner, Gardner, Glasgow, Good, Hecht, Janossy, Julius, Koszinowski, Labowskie, Lohmann-Mathes, Lundstedt, Marker, McFarland, Oldstone, Perlmann, Perlmann, Profitt, Schirrmacher, Shearer, Shortman, Speel, Steele, Ueda, Ueda, Von Pirquet, Wagner, Wagner, Zinkernagel, Zinkernagel   +36 more
core   +1 more source

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance None of the single-cell RNA sequencing (scRNA-seq) studies published so far convincingly identified human γδ T lymphocytes despite their anticancer functions.
Gabriele Pizzolato, H. Kaminski, M. Tosolini, D. Franchini, F. Pont, Frédéric Martins, Carine Valle, Delphine Labourdette, Sarah Cadot, A. Quillet-Mary, M. Poupot, C. Laurent, L. Ysebaert, S. Meraviglia, F. Dieli, P. Merville, P. Milpied, J. Déchanet-Merville, J. Fournié   +18 more
semanticscholar   +1 more source

Regional peculiarities of specific immunity in inhabitants of different mountain heights of the Kyrgyz Republic

Medicine Science, 2023
Kyrgyzstan's challenging natural conditions and fragile mountain ecosystems can weaken the immune system of individuals residing permanently in high-altitude areas.
Nasira Tiumonbaeva, Astra Kazybekova, Kaliyman Kasymalieva, Kancarbek Soburov   +3 more
doaj   +1 more source

Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus [PDF]

, 1975
VARIOUS virus infections lead to the formation of cytotoxic lymphocytes (CL), which are capable of killing virus-infected target cells1−4. Specific lysis of target cells infected with 51Cr-labelled vaccinia virus could be observed when investigating the ...
GJ Hämmerling, GM Shearer, H. ERTL, HR McFarland, I Gardner, LF Speel, M Nabholz, M Schlesinger, O Marker, RM Zinkernagel, RM Zinkernagel, RM Zinkernagel, RV Blanden, U. KOSZINOWSKI   +13 more
core   +1 more source