Results 21 to 30 of about 50 (50)
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Cytotoxic T lymphocytes against HIV
AIDS, 1990HIV-1 infection has clearly been shown to induce a vigorous CTL response in infected people, and this response is present at a time when immune function otherwise is globally impaired. HIV-1-specific CTL are detectable both in peripheral blood and tissues of infected people, and are aimed at multiple viral proteins.
Bruce D. Walker, Fernando Plata
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Cytotoxic Lymphocytes and Cardiac Electrophysiology
Journal of Molecular and Cellular Cardiology, 2002It is widely recognized that immune effector mechanisms contribute to cardiac dysfunction in major cardiac pathologies, such as myocarditis and the consequent dilated cardiomyopathy, Chagas' disease and heart transplant rejection. Of the wealth of immune mechanisms known to affect cardiac function, this review will deal with the adverse effects caused ...
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Killing Mechanisms of Cytotoxic T Lymphocytes
Physiology, 1998Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.
Luis Filgueira, Peter Groscurth
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Lymphocyte-Mediated Cytotoxicity [PDF]
, 2010 1 Cytotoxic Lymphocytes 2 CTLs and NK Cell Morphology and Function 3 Killing 4 Composition of Cytolytic Granules of CTLs and NK Cells 5 Killer Cell Self-Protection 6 Target Cell Death 7 Role of Perforin in the Induction of CTL Activation 8 Perforin Function in Homeostasis 9 Homeostatic Function of Fas and Fas-L 10 ...
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Cytotoxic T lymphocytes in herpesvirus infections
Veterinary Immunology and Immunopathology, 1984A. INTRODUCTION B. MEASUREMENT OF CTL AND THEIR DIFFERENTIATION FROM OTHER FORMS OF CYTOTOXICITY 1. The chromium re lease assay 2. S p e c i f i c i t y con t ro l s 3. I d e n t i f i c a t i o n of e f f e c t o r c e l l s w i th a l l o a n t i s e r a 4. Ef fec t of i n h i b i t o r s on CTL 5. Target c e l l s C.
Barry T. Rouse, David W. Horohov
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Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity
2003New functions are implicated for calreticulin, based on its release from cytotoxic NK and T cells. Calreticulin is the only one of six “KDEL” (Lys-Asp-Glu-Leu carboxy terminal) endoplasmic reticulum chaperone proteins present in cytotoxic granules of these lymphocytes.
Dorothy Hudig, Reza Karimi
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Targeting and Activation of Cytotoxic Lymphocytes
2015Des anticorps heteroconjugues ont permis d'etudier et de moduler la specificite des cellules cytotoxiques in vivo et in vitro. Il faut determiner quel anticorps bispecifique sera capable in vivo de «cibler» certaines cellules cytotoxiques qui pourront avoir des applications ...
David M. Segal, Denis P. Snider
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Cytotoxic T Lymphocytes in Resistance to Tuberculosis
1998Recent experimental evidence has suggested T cells recognizing antigens in the context of both classical MHC class I and nonclassical class I-like molecules contribute to protective responses against Mycobacterium tuberculosis (MTB) infection. Our aims were to characterize both types of T cells, and to explore the basis of communication between the ...
Barry R. Bloom +6 more
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Cytotoxic lymphocyte‐mediated immunotherapy
Australian and New Zealand Journal of Medicine, 1995Abstract:Cytotoxic CD8+ T cells and NK cells play a role in the elimination of some viruses, graft rejection, antitumour responses, immuno regulation and some autoimmune diseases. The central importance of these cells in each of these immune responses and the therapeutic potential they offer, when effectively targeted, has justified continued interest ...
Mark J. Smyth, Michael H. Kershaw
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The role of cytotoxicity in lymphocyte homeostasis
Current Opinion in Immunology, 2001Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune response and in lymphocyte homeostasis.
Alain Fischer +1 more
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