Results 51 to 60 of about 724,385 (326)

Cytotoxic T lymphocytes

Oncoimmunology, 2012
Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are characterized as a small population of cancer cells that have high tumor-initiating ability.
Y. Hirohashi, T. Torigoe, S. Inoda, R. Morita, V. Kochin, N. Sato   +5 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Inflammatory and immune variables as predictors of survival in dogs with myxomatous mitral valve disease

BMC Veterinary Research
Background We aimed to investigate the association between selected inflammatory and immune variables and survival of dogs with myxomatous mitral valve disease (MMVD).
Martina Cimerman, Natalia Druzhaeva, Alenka Nemec Svete, Melita Hajdinjak, Katka Pohar, Alojz Ihan, Aleksandra Domanjko Petrič   +6 more
doaj   +1 more source

Analysis of Cellular Component Indicators of Immune Status of Rhesus Macaques

Проблемы особо опасных инфекций, 2021
Objective. Selection of indicators of lymphocyte populations in rhesus macaques determined by flow cytometry to evaluate variations of cellular constituent of their immune status.Materials and methods.
G. V. Borisevich, S. L. Kirillova, O. N. Sidorova, V. N. Lebedev, A. A. Petrov, A. V. Ovchinnikov, I. V. Shatokhina, T. E. Sizikova, V. E. Sazonov, E. S. Mukhacheva, S. V. Borisevich   +10 more
doaj   +1 more source

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

Journal of Experimental Medicine, 1998
This study describes the construction of soluble major histocompatibility complexes consisting of the mouse class I molecule, H-2Db, chemically biotinylated β2 microglobulin and a peptide epitope derived from the glycoprotein (GP; amino acids 33–41) of ...
A. Gallimore, A. Glithero, A. Godkin, A. Tissot, A. Plückthun, T. Elliott, H. Hengartner, R. Zinkernagel   +7 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo, Anderson, Boumsell, Byhardt, Catovsky, Durum, Enno, Foa, Foa, Herrman, Horning, Johnson, Markey, Martin, McCann, Mills, Mittelman, Paule, Platsoucas, Roncadin, Rovston, Spivak, Terstappen, Terstappen, Vann   +24 more
core   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells

Сеченовский вестник
Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures ...
T. M. Kulinich, Ya. Yu. Kiseleva, A. M. Shishkin, E. A. Kudinova, O. B. Knyazeva, R. Ranjit, V. K. Bozhenko, V. A. Solodky   +7 more
doaj   +1 more source

CYTOTOXIC LYMPHOCYTES: THE ROLE IN INFLAMMATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATION AND REMISSION

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Despite the number of publications related to the expression of surface antigens of periphery blood lymphocytes in chronic obstructive pulmonary disease (COPD), algorithm for interpreting of the results and implicating pathogene-tic ...
N. A. Raspopina, E. G. Shuganov, F. N. Paleev, Zh. M. Salmasi, A. E. Shuganov   +4 more
doaj   +1 more source