Results 71 to 80 of about 564,677 (319)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells

Сеченовский вестник
Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures ...
T. M. Kulinich, Ya. Yu. Kiseleva, A. M. Shishkin, E. A. Kudinova, O. B. Knyazeva, R. Ranjit, V. K. Bozhenko, V. A. Solodky   +7 more
doaj   +1 more source

CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA

Alʹmanah Kliničeskoj Mediciny, 2016
Background: To improve differential diagnosis of chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), identification of new biological markers is needed.
E. G. Shuganov, N. A. Raspopina, Zh. M. Salmasi   +2 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

CYTOTOXIC LYMPHOCYTES: THE ROLE IN INFLAMMATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATION AND REMISSION

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Despite the number of publications related to the expression of surface antigens of periphery blood lymphocytes in chronic obstructive pulmonary disease (COPD), algorithm for interpreting of the results and implicating pathogene-tic ...
N. A. Raspopina, E. G. Shuganov, F. N. Paleev, Zh. M. Salmasi, A. E. Shuganov   +4 more
doaj   +1 more source

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

Journal of Experimental Medicine, 1998
This study describes the construction of soluble major histocompatibility complexes consisting of the mouse class I molecule, H-2Db, chemically biotinylated β2 microglobulin and a peptide epitope derived from the glycoprotein (GP; amino acids 33–41) of ...
A. Gallimore, A. Glithero, A. Godkin, A. Tissot, A. Plückthun, T. Elliott, H. Hengartner, R. Zinkernagel   +7 more
semanticscholar   +1 more source

Lymphocyte Cytotoxicity in Alcoholic Hepatitis

Gastroenterology, 1977
Studies were undertaken to evaluate the cytotoxicity of peripheral lymphocytes obtained from patients with alcoholic hepatitis. Lymphocyte cytotoxicity to Chang liver cells was investigated by a microcytotoxicity test, and that to autologous liver cells obtained by percutaneous liver biopsy was studied using a 51Cr release assay.
Carroll M. Leevy, Shinichi Kakumu
openaire   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Cytotoxic B Cells in Relapsing-Remitting Multiple Sclerosis Patients

Frontiers in Immunology, 2022
BackgroundEmerging evidence of antibody-independent functions, as well as the clinical efficacy of anti-CD20 depleting therapies, helped to reassess the contribution of B cells during multiple sclerosis (MS) pathogenesis.ObjectiveTo investigate whether ...
Vinícius O. Boldrini, Vinícius O. Boldrini, Ana M. Marques, Raphael P. S. Quintiliano, Adriel S. Moraes, Carla R. A. V. Stella, Carla R. A. V. Stella, Ana Leda F. Longhini, Ana Leda F. Longhini, Irene Santos, Marília Andrade, Breno Ferrari, Alfredo Damasceno, Rafael P. D. Carneiro, Rafael P. D. Carneiro, Carlos Otávio Brandão, Carlos Otávio Brandão, Alessandro S. Farias, Alessandro S. Farias, Alessandro S. Farias, Alessandro S. Farias, Leonilda M. B. Santos, Leonilda M. B. Santos   +22 more
doaj   +1 more source

Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines [PDF]

arXiv, 2020
A library of substituted pyrimidines was synthesized and evaluated for free radical scavenging, and in vitro cytotoxic activity in 3T3 cells. All compounds showed good free radical scavenging activity with IC50 values in the range of 42.9 + 0.31 to 438.3 3.3 {\mu}M as compared to the standard butylated hydroxytoluene having IC50 value of 128.83 2.
arxiv