Results 51 to 60 of about 176,443 (228)
A gene regulatory network armature for T lymphocyte specification [PDF]
Proceedings of the National Academy of Sciences, 2008 Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process, we have used high-resolution analysis of regulatory gene expression ...
Georgescu, Constantin +7 more
openaire +3 more sources
Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]
, 2015 BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu +3 more
core +2 more sources
Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]
, 2020 Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis +15 more
core +2 more sources
Virology Journal, 2011 Back ground Chandipura virus produces acute infection in mice. During infection drastic reduction of CD4+, CD8+ and CD19 + cell was noticed. Depletion of lymphocytes also noticed in spleen.
Shahir Prajakta, Anukumar Balakrishnan
doaj +1 more source
CD8+ T Lymphocytes: Crucial Players in Sjögren’s Syndrome
Frontiers in Immunology, 2021 Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands.
Huimin Zhou +5 more
doaj +1 more source
Predictors of Immunosuppressive Regulatory T Lymphocytes in Healthy Women [PDF]
Journal of Cancer Epidemiology, 2012 Immunosuppressive regulatory T (Treg) cells play an important role in antitumor immunity, self-tolerance, transplantation tolerance, and attenuation of allergic response. Higher proportion of Treg cells has been observed in peripheral blood of cancer cases compared to controls.
Hampras, Shalaka S. +6 more
openaire +2 more sources
Медицинский вестник Юга РоссииObjective: to evaluate the dynamics of the T- and B-cell immunity in patients with acute coronary syndrome (ACS) who have and have not had COVID-19, depending on the number of CD3+CD8+T-lymphocytes.Materials and methods: 65 men with ACS who underwent ...
E. A. Safronova +4 more
doaj +1 more source
Myocardial aging as a T-cell–mediated phenomenon [PDF]
, 2017 In recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies.
Abeßer, Marco +15 more
core +1 more source
CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation
Seminars in Immunology, 2006 Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens.
Joffre, Olivier, van Meerwijk, Joost
openaire +3 more sources
The Influence of the Regulatory T Lymphocytes on Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Atherosclerosis is complex inflammatory disease of the arterial wall, in which T lymphocytes play a significant role.1 Since the recognition that T lymphocytes are present in human atherosclerotic plaque nearly 2 decades ago,2 research has focused on the functional importance of these cells in the atherosclerotic process.
Israel, Gotsman +2 more
openaire +2 more sources