Results 51 to 60 of about 235,846 (125)

Prognostic significance of CD4-positive regulatory T cells in tumor draining lymph nodes from patients with bladder cancer

open access: yesHeliyon, 2020
Introduction and methods: To clarify the role of CD4+ regulatory T cells in bladder cancer, we investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow ...
Ali Ariafar   +5 more
doaj  

Dynamic causal modelling of immune heterogeneity [PDF]

open access: yesarXiv, 2020
An interesting inference drawn by some Covid-19 epidemiological models is that there exists a proportion of the population who are not susceptible to infection -- even at the start of the current pandemic. This paper introduces a model of the immune response to a virus.
arxiv  

Phenotypic divergence of Homo sapiens is driven by the evolution of human-specific genomic regulatory networks via two mechanistically distinct pathways of creation of divergent regulatory DNA sequences [PDF]

open access: yesarXiv, 2015
Thousands of candidate human-specific regulatory sequences (HSRS) have been identified, supporting the hypothesis that unique to human phenotypes result from human-specific alterations of genomic regulatory networks. Here, conservation patterns analysis of 18,364 candidate HSRS was carried out based on definition of the sequence conservation threshold ...
arxiv  

T cells expressing the γδ receptor are essential for Th2-mediated inflammation in patients with acute exacerbation of asthma

open access: yesMediators of Inflammation, 2002
Objective: T lymphocytes have a central regulatory role in the pathogenesis of asthma. The objective of this study was to characterize immunologically the activation stage of asthma and the functional profile of lymphocytes from induced sputum, with ...
Agnès Hamzaoui   +3 more
doaj   +1 more source

Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes

open access: yesMediators of Inflammation, 2017
We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes.
Kyu Hwan Kwack, Hyeon-Woo Lee
doaj   +1 more source

Dynamics of Activation and Regulation of the Immune Response to Attack by Viral Pathogens Using Mathematical Modeling

open access: yesMathematics
In this paper, a mathematical model is developed to simulate the activation of regulatory T lymphocytes dynamics. The model considers the adaptive immune response and consists of epithelial cells, infected cells, free virus particles, helper and ...
Ledyz Cuesta-Herrera   +4 more
doaj   +1 more source

IMMUNOREGULATORY IMBALANCE AND FUNCTIONAL STATE OF THE HEART IN THE PATIENTS WITH DIABETES MELLITUS TYPE 2

open access: yesМедицинская иммунология, 2018
Diabetes mellitus type 2 is one of the most important non-infectious diseases in the modern world, being an important risk factor of cardiovascular disorders.
I. V. Kologrivova   +5 more
doaj   +1 more source

The New Anticipatory Governance Culture for Innovation: Regulatory Foresight, Regulatory Experimentation and Regulatory Learning [PDF]

open access: yes(2025) 6(1) European Business Organization Law Review
With the rapid pace of technological innovation, traditional methods of policy formation and legislating are becoming conspicuously anachronistic. The need for regulatory choices to be made to counter the deadening effect of regulatory lag is more important to developing markets and fostering growth than achieving one off regulatory perfection.
arxiv  

Optimal Strategies for Virus Propagation [PDF]

open access: yesarXiv, 2015
This paper explores a number of questions regarding optimal strategies evolved by viruses upon entry into a vertebrate host. The infected cell life cycle consists of a non-productively infected stage in which it is producing virions but not releasing them and of a productively infected stage in which it is just releasing virions. The study explores why
arxiv  

Association of FoxP3+ T regulatory lymphocytes with epicardial adipose tissue thickness in patients with coronary heart disease

open access: yesActa Biomedica Scientifica
Background. Increase ofthe epicardial adipose tissue (EAT) thickness isassociated with development of inflammation and cardiovascular complications, however, there is no data on the relationship between EAT thickening and the number of immunosuppressive ...
I. V. Kologrivova   +5 more
doaj   +1 more source

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