Cyclin kinase inhibitor p21: a mediator of immune tolerance: direct and indirect evidence [PDF]
, 2009 *Background:* Uncontrolled proliferation of T-cells is considered a barrier to the induction of transplantation tolerance by T regulatory cells. Therefore, cyclin kinase inhibitor p21, one of the most potent inhibitors of cell proliferation, may exert an
Ashwani Khanna
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Frontiers in Immunology, 2022 T cells and B cells have been identified in human and murine islets, but the phenotype and role of islet lymphocytes is unknown. Resident immune populations set the stage for responses to inflammation in the islets during homeostasis and diabetes.
Jennifer C. Whitesell +13 more
doaj +1 more source
Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis [PDF]
Respiratory Research, 2006 There is a growing body of evidence to suggest that CD8+ T lymphocytes contribute to local allergen-induced eosinophilic inflammation. Since bone marrow (BM) responses are intricately involved in the induction of airway eosinophilia, we hypothesized that CD8+ T lymphocytes, as well as CD4+ T lymphocytes, may be involved in this process.Several ...
Bossios Apostolos +7 more
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Foxp3+ T-lymphocytes in the pathogenesis of mycosis fungoides
Vestnik Dermatologii i Venerologii, 2017 The pathogenesis of mycosis fungoides (MF) is not fully understood, nevertheless it is believed that the microenvironment of the tumor cells could influence the development of malignant lymphocytes. T-regulatory cells are a specialized subpopulation of T-
A. S. Zhukov +2 more
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Tumor-Infiltrating γδ T Cells Suppress T and Dendritic Cell Function via Mechanisms Controlled by a Unique Toll-like Receptor Signaling Pathway [PDF]
, 2007 Summaryγδ T cells are important contributors to innate immunity against cancer, but their regulatory role in controlling immune responses remains largely unknown.
Guangyong Peng +53 more
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The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]
, 2016 Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L. +6 more
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ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
Медицинская иммунология, 2014 We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by ...
I. V. Nekrasova +2 more
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Can plasma exchange therapy induce regulatory T lymphocytes in multiple sclerosis patients? [PDF]
, 2012 Plasma exchange is used increasingly as an individual therapeutic decision for treating of severe, steroid-resistant relapses of multiple sclerosis (MS).
Gharagozloo, M., Jamshidian, A.
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Molecular Autism, 2021 Background Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients ...
Pierre Ellul +7 more
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Regulatory T cells in children with recently diagnosed type 1 diabetes
Indian Journal of Endocrinology and Metabolism, 2012 Background: Regulatory T cells have an important role in the control of immune reactivity against self antigens and probably play a role in pathogenesis of type 1 diabetes (T1D).
Asmaa Mohamed Zahran +2 more
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