Results 61 to 70 of about 235,846 (125)

Foxp3 expression is associated with aggressiveness in differentiated thyroid carcinomas

Clinics, 2012
OBJECTIVES: Forkhead box P3 (FoxP3) expression has been observed in human cancer cells but has not yet been reported in thyroid cells. We investigated the prognostic significance of both FoxP3 expression and intratumoral FoxP3+ lymphocyte infiltration in
Lucas Leite Cunha, Elaine Cristina Morari, Suely Nonogaki, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward   +5 more
doaj   +1 more source

Measuring the temperature and diversity of the U.S. regulatory ecosystem [PDF]

arXiv, 2016
Over the last 23 years, the U.S. Securities and Exchange Commission has required over 34,000 companies to file over 165,000 annual reports. These reports, the so-called "Form 10-Ks," contain a characterization of a company's financial performance and its risks, including the regulatory environment in which a company operates.
arxiv  

Is prokaryotic complexity limited by accelerated growth in regulatory overhead? [PDF]

arXiv, 2003
Increased biological complexity is generally associated with the addition of new genetic information, which must be integrated into the existing regulatory network that operates within the cell. General arguments on network control, as well as several recent genomic observations, indicate that regulatory gene number grows disproportionally fast with ...
arxiv  

GeneNetMiner: accurately mining gene regulatory networks from literature [PDF]

arXiv, 2014
GeneNetMiner is standalone software which parses the sentences of iHOP and captures regulatory relations. The regulatory relations are either gene gene regulations or gene biological processes relations. Capturing of gene biological process relations is a unique feature for the tools of this kind. These relations can be used to build up gene regulatory
arxiv  

Regulator-Manufacturer AI Agents Modeling: Mathematical Feedback-Driven Multi-Agent LLM Framework [PDF]

arXiv
The increasing complexity of regulatory updates from global authorities presents significant challenges for medical device manufacturers, necessitating agile strategies to sustain compliance and maintain market access. Concurrently, regulatory bodies must effectively monitor manufacturers' responses and develop strategic surveillance plans.
arxiv  

Differences in immunological profile in atopic dermatitis patients with and without dupilumab therapy

Immunological Medicine
Our aim is to determine the number of leukocytes, T lymphocytes and B lymphocytes and the expression of activation markers CD200 and CD23 on B lymphocytes in atopic dermatitis (AD) patients (treated and not treated with dupilumab) during the pollen ...
Jarmila Čelakovská, Eva Čermáková, Petra Boudková, Ctirad Andýs, Jan Krejsek   +4 more
doaj   +1 more source

Regulatory Functions from Cells to Society [PDF]

arXiv
Regulatory functions are essential in both socioeconomic and biological systems, from corporate managers to regulatory genes in genomes. Regulatory functions come with substantial costs, but are often taken for granted. Here, we empirically examine regulatory costs across diverse systems -- biological organisms (bacteria and eukaryotic genomes), human ...
arxiv  

BACH2: The Future of Induced T-Regulatory Cell Therapies

Cells
BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes.
Daniel Zwick, Mai Tram Vo, Young Jun Shim, Helena Reijonen, Jeong-su Do   +4 more
doaj   +1 more source

Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state

Frontiers in Immunology
Conventional CD4+ T lymphocytes consist of naïve, foreign antigen-specific memory, and self-antigen-driven memory-phenotype (MP) cell compartments at homeostasis.
Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Naoto Ishii, Jinfang Zhu, Takeshi Kawabe, Takeshi Kawabe   +8 more
doaj   +1 more source

RIRAG: Regulatory Information Retrieval and Answer Generation [PDF]

arXiv
Regulatory documents, issued by governmental regulatory bodies, establish rules, guidelines, and standards that organizations must adhere to for legal compliance. These documents, characterized by their length, complexity and frequent updates, are challenging to interpret, requiring significant allocation of time and expertise on the part of ...
arxiv