Results 151 to 160 of about 688,743 (255)

Tumor-Immune-On-Chip to Evaluate Pathophysiological Feature of T Lymphocytes Expanded from Patient Tumors and Lymph Node Tissues. [PDF]

Cancer Med
Cho GB, Lee HJ, Heo YJ, Ko J, Lee WS, Hyung S.   +5 more
europepmc   +1 more source

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source

DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation. [PDF]

EMBO Rep
Niven J, Kucuk S, Gope A, Certo M, Cassidy FC, Arana Echarri A, Ali S, Ladoukakis E, Vidali S, Macchi C, Amir SS, Bergin R, Davies S, Perkin OJ, Smith J, Cucchi D, Heneghan H, Wijesinghe S, Jenkins BJ, Baig S, Mahony C, Chidomere C, Sarkar S, Nicolaou A, Caamaño J, Croft A, Davies E, Thompson D, O'Shea D, Jones SW, Duggal NA, Ruscica M, Makarova M, Jones N, Da Silva Xavier G, Geberhiwot T, Turner JE, Hogan AE, Nedjai B, Mauro C.   +39 more
europepmc   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Metabolic Glycoengineering Enables Fluorine-18 Radiolabeling of T Lymphocytes via Dual-Bioorthogonal Chemistry. [PDF]

Bioconjug Chem
Biti A, Centanni A, Imlimthan S, Harjunpää H, Sukhova A, Wiedmer SK, Fagerholm S, Sarparanta M.   +7 more
europepmc   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Intracellular ATP Levels in CD4⁺ T Lymphocytes as a Prognostic Marker for 28-Day Mortality in Adult ICU Patients with Sepsis: A Retrospective Study. [PDF]

J Inflamm Res
Fan L, Hu H, Liang Z, Cai Y, Liu Q, Li S, Xie W, Zou Z, Liu Y.   +8 more
europepmc   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Correction to "Rhinovirus Infects B and CD4 T Lymphocytes in Hypertrophic Tonsils in Children". [PDF]

J Med Virol
europepmc   +1 more source

Phenotypes and mechanisms of dysfunctional cardiac T-lymphocytes in dilated cardiomyopathy patients. [PDF]

J Mol Cell Cardiol
Angelotti A, Ponnusamy T, Kumar V, Passarelli GV, Malysz J, Mahesh B, Soleimani B, Bradley EA, Bansal SS.   +8 more
europepmc   +1 more source