Results 171 to 180 of about 13,171,622 (345)

Metabolic regulation of T lymphocytes.

Annual Review of Immunology, 2013
Nancie J. MacIver, Ryan D. Michalek, J. Rathmell   +2 more
semanticscholar   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Initial characterization of ruminal T lymphocytes in lactating dairy cows. [PDF]

JDS Commun
Vandevoorde L, Krogstad K.
europepmc   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Association between hypertensive patients of Kazakh nationality in Xinjiang and T lymphocytes microRNAs. [PDF]

Medicine (Baltimore)
Dong J, Jiao M, Chao Y, Gao B, Zhang Y.
europepmc   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Spaceflight alters the immune regulatory functions of neutrophil granulocytes on T lymphocytes. [PDF]

iScience
Tavukçuoğlu E, Yanık H, Güven HE, Yılmaz KB, Esendağlı G.   +4 more
europepmc   +1 more source

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America, 2005
E. Sato, S. Olson, Jiyoung Ahn, B. Bundy, H. Nishikawa, F. Qian, A. Jungbluth, D. Frosina, S. Gnjatic, C. Ambrosone, J. Kepner, Tosin Odunsi, G. Ritter, S. Lele, Yao-Tseng Chen, H. Ohtani, L. Old, K. Odunsi   +17 more
semanticscholar   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

Nature Medicine, 2014
Luzhou Xing, Z. Dai, A. Jabbari, J. Cerise, C. Higgins, Weijuan Gong, A. Jong, S. Harel, G. Destefano, Lisa Rothman, Pallavi Singh, L. Petukhova, Julian M. Mackay-Wiggan, A. Christiano, R. Clynes   +14 more
semanticscholar   +1 more source