Results 161 to 170 of about 13,171,622 (345)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

BATF3 regulates differentiation of CD8⁺ T lymphocytes and memory differentiation program. [PDF]

Life Sci Alliance
Umemura K, Kojima Y, Julamanee J, Okuno Y, Takeuchi Y, Ohara F, Kuwano S, Adachi Y, Hanajiri R, Terakura S, Kiyoi H.   +10 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Rhinovirus Infects B and CD4 T Lymphocytes in Hypertrophic Tonsils in Children. [PDF]

J Med Virol
Martins R, de Paula FE, Mitchell TBG, Criado MF, Cardoso RS, Jesus BLS, Castro IA, Cassiano MHA, Rodrigues DMR, Oliveira N, Carenzi L, Valera FC, Tamashiro E, Anselmo-Lima WT, Arruda E.   +14 more
europepmc   +1 more source

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

Science, 2002
M. Dudley, J. Wunderlich, P. Robbins, J. Yang, P. Hwu, D. Schwartzentruber, S. Topalian, R. Sherry, N. Restifo, Amy M. Hubicki, M. Robinson, M. Raffeld, P. Duray, C. Seipp, Linda J. Rogers-Freezer, K. Morton, S. Mavroukakis, D. White, S. Rosenberg   +18 more
semanticscholar   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Specific Deficiency of Naïve CD4+ T Lymphocytes Characterizes Heart Failure and Heightens Mortality Risk in the HRS. [PDF]

J Am Heart Assoc
Zidar DA, Freeman ML, Wilson BM, Al-Kindi S, Chung MK, Gunzler DD, Parikh SA, Sharma AA, Shive CL, Jain M, Skarbinski J, Tang WHW, Dalton JE, Anthony DD, Chan TA, Thyagarajan B.   +15 more
europepmc   +1 more source

T lymphocytes in psoriasis [PDF]

, 1995
Debets, J.E.M.A. (Reno), Hegmans, J.P.J.J. (Joost), Prens, E.P. (Errol)   +2 more
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Phenotypes and mechanisms of dysfunctional cardiac T-lymphocytes in dilated cardiomyopathy patients. [PDF]

J Mol Cell Cardiol
Angelotti A, Ponnusamy T, Kumar V, Passarelli GV, Malysz J, Mahesh B, Soleimani B, Bradley EA, Bansal SS.   +8 more
europepmc   +1 more source