Results 11 to 20 of about 12,051,773 (333)

Reprogrammed CD8⁺ T-Lymphocytes Isolated from Bone Marrow Have Anticancer Potential in Lung Cancer

Biomedicines, 2022
CD8+ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector T-lymphocytes largely limits the effectiveness of therapy.
Evgenii G. Skurikhin, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Mariia Zhukova, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey G. Morozov, Aslan Kubatiev, Alexander Dygai   +12 more
doaj   +1 more source

NFAT2 regulates generation of innate-like CD8+ T lymphocytes and CD8+ T lymphocytes responses

Frontiers in Immunology, 2016
NFAT2 null mutant mice die in utero of cardiac failure, precluding analysis of the role of NFAT2 in lymphocyte responses. Only the NFAT2-/-/Rag-1-/- chimeric mice model gave insight into the role of NFAT2 transcription factor in T lymphocyte development,
Emilia Pachulec, Vanessa Neitzke-Montinelli, Joao P.B. Viola   +2 more
doaj   +1 more source

"Proliferation of cytotoxic and activated T cells during acute Epstein-Barr virus induced Infectious Mononucleosis " [PDF]

Acta Medica Iranica, 2002
The immune responses that develop following Epstien-Barr Virus (EBV) infection are complex and involve both humoral and to a greater extent cell-mediated immune mechanisms. To evaluate the immune response, flow cytometric analysis of the peripheral blood
Mansoori SD, Shahgasempour S
doaj   +2 more sources

Capturing T Lymphocytes’ Dynamic Interactions With Human Neural Cells Using Time-Lapse Microscopy

Frontiers in Immunology, 2021
To fully perform their functions, T lymphocytes migrate within organs’ parenchyma and interact with local cells. Infiltration of T lymphocytes within the central nervous system (CNS) is associated with numerous neurodegenerative disorders.
Florent Lemaître, Florent Lemaître, Ana Carmena Moratalla, Ana Carmena Moratalla, Negar Farzam-kia, Negar Farzam-kia, Yves Carpentier Solorio, Yves Carpentier Solorio, Olivier Tastet, Aurélie Cleret-Buhot, Jean Victor Guimond, Elie Haddad, Nathalie Arbour, Nathalie Arbour   +13 more
doaj   +1 more source

Production of CD87 Antigen-Specific CAR-T Lymphocytes and Assessment of Their In Vitro Functional Activity

Клиническая онкогематология, 2022
Aim. To generate anti-CD87 CAR-T lymphocytes and to assess their in vitro functional activity. Materials & Methods. Т-lymphocytes isolated from healthy donor peripheral blood were transduced with the anti-CD87-CAR, T2A, and FusionRed gene coding ...
M. V. Neklesova, Sergei Vladimirovich Smirnov, A. A. Shatilova, K. A. Levchuk, A. E. Ershova, S. A. Silonov   +5 more
doaj   +1 more source

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance None of the single-cell RNA sequencing (scRNA-seq) studies published so far convincingly identified human γδ T lymphocytes despite their anticancer functions.
Gabriele Pizzolato, H. Kaminski, M. Tosolini, D. Franchini, F. Pont, Frédéric Martins, Carine Valle, Delphine Labourdette, Sarah Cadot, A. Quillet-Mary, M. Poupot, C. Laurent, L. Ysebaert, S. Meraviglia, F. Dieli, P. Merville, P. Milpied, J. Déchanet-Merville, J. Fournié   +18 more
semanticscholar   +1 more source

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

Neurobiology of Disease, 2012
Activated microglia and infiltrating lymphocytes are neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), a fatal motoneuron disease.
Weihua Zhao, David R. Beers, Bing Liao, Jenny S. Henkel, Stanley H. Appel   +4 more
doaj   +1 more source

ANTI-APOPTOTIC EFFECT OF CD95 RECEPTOR IN NA VE CD8+ T-LYMPHOCYTES IN CHILDREN WITH ACUTE INFECTIOUS MONONUCLEOSIS

Инфекция и иммунитет, 2016
Acute infectious mononucleosis is a widespread viral disease, which most often manifests in childhood. The development of acute infectious mononucleosis is accompanied by the change of the CD4+/CD8+ T-lymphocytes ratio and the increase of the virus ...
E. N. Filatova, E. V. Anisenkova, N. B. Presnyakova, T. D. Sycheva, E. A. Kulova, O. V. Utkin   +5 more
doaj   +1 more source

Near-infrared imaging of adoptive immune cell therapy in breast cancer model using cell membrane labeling. [PDF]

PLoS ONE, 2014
The overall objective of this study is to non-invasively image and assess tumor targeting and retention of directly labeled T-lymphocytes following their adoptive transfer in mice.
Fatma M Youniss, Gobalakrishnan Sundaresan, Laura J Graham, Li Wang, Collin R Berry, Gajanan K Dewkar, Purnima Jose, Harry D Bear, Jamal Zweit   +8 more
doaj   +1 more source

Ca2+ Microdomains in T-Lymphocytes

Frontiers in Oncology, 2017
Early Ca2+ signaling is characterized by occurrence of Ca2+ microdomains formed by opening of single or clusters of Ca2+ channels, thereby initiating first signaling and subsequently activating global Ca2+ signaling mechanisms. However, only few data are
Andreas H. Guse, Insa M. A. Wolf
doaj   +1 more source