Results 31 to 40 of about 10,198,101 (175)
Immunotherapy-Induced Glomerulonephritis: Whodunit?
Graduate Medical Education Research Journal, 2023 Mentor: Ketki Tendulkar Program: Nephrology Type: Case Report Background: Kidney immune-related adverse events are well recognized side effects of immune checkpoint inhibitor therapy.
Brian Benes +4 more
doaj +1 more source
Frontiers in Oncology, 2020 Background: Mucosal melanomas including melanomas of the urogenital tract represent a rare type of melanoma characterized by low mutational burden and poor prognosis.
Anne Fröhlich +8 more
doaj +1 more source
Melanoma Management, 2019 Aim: Talimogene laherparepvec (T-VEC) is an intralesional treatment for unresectable cutaneous, subcutaneous and nodal melanoma. COSMUS-1 was conducted to examine how T-VEC is used in US clinical practice.
Matthew C Perez +9 more
doaj +1 more source
OncoImmunology, 2019 Successful immunotherapy for melanoma depends on the recruitment of effector CD8+ T cells to the tumor microenvironment. Factors contributing to T cell regulation in melanoma have recently been recognized, including the stimulator of interferon genes ...
Praveen K. Bommareddy +3 more
doaj +1 more source
Loss of GRB2 associated binding protein 1 in arteriosclerosis obliterans promotes host autophagy
Chinese Medical Journal, 2021 . Background:. Arteriosclerosis obliterans (ASO) is a major cause of adult limb loss worldwide. Autophagy of vascular endothelial cell (VEC) contributes to the ASO progression. However, the molecular mechanism that controls VEC autophagy remains unclear.
Meng Ye +10 more
doaj +1 more source
T-VEC for Cancer Therapy: Applications, Limitations, and Potentials
Highlights in Science, Engineering and Technology, 2022 Cancer is a great threat to human health, and immunotherapy has become an important means to treat cancer in recent years. Talimogene laherparepvec (T-VEC), as an oncolytic virus, is one of the immunotherapy for melanoma. This article explains its mechanism, and then summarizes its clinical applications, including the effects and safety of monotherapy ...
openaire +1 more source
Oriented Chromatic Number of Cartesian Products Pm □ Pn and Cm □ Pn
Discussiones Mathematicae Graph Theory, 2022 We consider oriented chromatic number of Cartesian products of two paths Pm □ Pn and of Cartesian products of paths and cycles, Cm □ Pn. We say that the oriented graph G→\vec G is colored by an oriented graph H→\vec H if there is a homomorphism from G ...
Nenca Anna
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background Talimogene laherparepvec (T-VEC), an oncolytic virus, was designed to selectively replicate in and lyse tumor cells, releasing tumor-derived antigen to stimulate a tumor-specific immune response.Methods In this phase II study in patients with ...
Dirk Schadendorf +10 more
doaj +1 more source
Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial. [PDF]
Ann Surg Oncol, 2016 PURPOSE: Talimogene laherparepvec (T-VEC) is an oncolytic immunotherapy designed to induce tumor regression of injected lesions through direct lytic effects, and of uninjected lesions through induction of systemic antitumor immunity.
Andtbacka RH +12 more
europepmc +3 more sources
Scientific Reports, 2021 Talimogene laherparepvec (T-VEC) is an immunotherapy that generates local tumor lysis and systemic antitumor immune response. We studied the efficacy of intratumoral administration of T-VEC as monotherapy for inoperable locoregional recurrence of breast ...
Megumi Kai +13 more
doaj +1 more source