Results 1 to 10 of about 67,765 (183)

Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults. [PDF]

PLoS Neglected Tropical Diseases, 2013
BackgroundAdults with chronic Trypanosoma cruzi exhibit a poorly functional T cell compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T cells and increased levels of terminally differentiated T cells.
María C Albareda, Ana M De Rissio, Gonzalo Tomas, Alicia Serjan, María G Alvarez, Rodolfo Viotti, Laura E Fichera, Mónica I Esteva, Daniel Potente, Alejandro Armenti, Rick L Tarleton, Susana A Laucella   +11 more
doaj   +5 more sources

Cytotaxonomy of Trypanosoma cruzi (Chagas, 1909): Differentiation of T. cruzi I (TcI) and T. cruzi II (TcII) Genotypes Using Cytogenetic Markers. [PDF]

Am J Trop Med Hyg, 2019
Chagas disease is a public health problem caused by the Trypanosoma cruzi, and the T. cruzi I (TcI) and T. cruzi II (TcII) groups are considered important genotypes from the clinical point of view. Currently, the groups need to be molecularly analyzed for their identification; thus, we cytogenetically analyzed these groups with the objective of ...
Oliveira ABB, Ribeiro AR, Madeira FF, Cesaretto NR, da Rosa JA, Azeredo-Oliveira MTV, Alevi KCC.   +6 more
europepmc   +5 more sources

Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Javier M. Urquiza, Javier M. Urquiza, Juan M. Burgos, Juan M. Burgos, Diego S. Ojeda, Diego S. Ojeda, Carla A. Pascuale, Carla A. Pascuale, M. Susana Leguizamón, M. Susana Leguizamón, Jorge F. Quarleri, Jorge F. Quarleri   +11 more
doaj   +3 more sources

Protective role of TRPV1+ nociceptive neurons communication to macrophages against T. cruzi infection in mice [PDF]

Brain, Behavior, & Immunity - Health
Chagas’ disease is a life-threatening condition caused by Trypanosoma cruzi. Patients with chronic disease may develop gastrointestinal, neurological, or associated neuro-digestive dysfunctions. CNS invasion by T.
Sergio M. Borghi, Aparecida D. Malvezi, Maria Isabel Lovo-Martins, Victor Fattori, Tiago H. Zaninelli, Mariana M. Bertozzi, Camila R. Ferraz, Thiago M. Cunha, Rubia Casagrande, Marli C. Martins-Pinge, Phileno Pinge-Filho, Waldiceu A. Verri, Jr.   +11 more
doaj   +2 more sources

Editorial: Unravelling T. cruzi Biology. [PDF]

Front Cell Infect Microbiol, 2020
Taylor MC, Lander N, Yoshida N.
europepmc   +5 more sources

Cardiomyocyte oxidants production may signal to T. cruzi intracellular development. [PDF]

PLoS Negl Trop Dis, 2017
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, presents a variable clinical course, varying from asymptomatic to serious debilitating pathologies with cardiac, digestive or cardio-digestive impairment. Previous studies using two clonal T. cruzi populations, Col1.7G2 (T. cruzi I) and JG (T.
Dias PP, Capila RF, do Couto NF, Estrada D, Gadelha FR, Radi R, Piacenza L, Andrade LO.   +7 more
europepmc   +5 more sources

Assessing anti-T. cruzi candidates in vitro for sterile cidality. [PDF]

Int J Parasitol Drugs Drug Resist, 2016
Total clearance of the T. cruzi infection - referred to herein as "sterile cure" - seems to be a critical prerequisite for new drug candidates for Chagas disease, ensuring long-term beneficial effects for patients in the chronic indeterminate stage. This requirement is notably supported by the recent findings of clinical studies involving posaconazole ...
Cal M, Ioset JR, Fügi MA, Mäser P, Kaiser M.   +4 more
europepmc   +5 more sources

How to improve the early diagnosis of Trypanosoma cruzi infection: Relationship between validated conventional diagnosis and quantitative DNA amplification in congenitally infected children [PDF]

, 2013
BACKGROUND: According to the Chagas congenital transmission guides, the diagnosis of infants, born to Trypanosoma cruzi infected mothers, relies on the detection of parasites by INP micromethod, and/or the persistence of T. cruzi specific antibody titers
Bua, Jacqueline Elena, Cardoni, Rita Liliana, de Rissio, Ana María, Perrone, Alina Elizabeth, Ruiz, Andrés Mariano, Scollo, Karenina, Velázquez, Elsa Beatriz, Volta, Bibiana Julieta   +7 more
core   +21 more sources

Ancestral genomes, sex, and the population structure of Trypanosoma cruzi. [PDF]

PLoS Pathogens, 2006
Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75 strains of the parasite with five nuclear microsatellite loci, 24Salpha RNA genes, and sequence ...
Jorge M de Freitas, Luiz Augusto-Pinto, Juliana R Pimenta, Luciana Bastos-Rodrigues, Vanessa F Gonçalves, Santuza M R Teixeira, Egler Chiari, Angela C V Junqueira, Octavio Fernandes, Andréa M Macedo, Carlos Renato Machado, Sérgio D J Pena   +11 more
doaj   +2 more sources

Trypanosoma cruzi-infected triatomines and rodents co-occur in a coastal island of northern Chile [PDF]

PeerJ, 2020
Trypanosoma cruzi, the cause agent of Chagas disease, is transmitted mainly by blood-feeding insects of the subfamily Triatominae. The T. cruzi life cycle alternates between triatomines and mammalian hosts, excluding birds and reptiles.
Ricardo Campos-Soto, Gabriel Díaz-Campusano, Nicol Quiroga, Catalina Muñoz-San Martín, Ninette Rives-Blanchard, Fernando Torres-Pérez   +5 more
doaj   +2 more sources