Results 11 to 20 of about 12,032,280 (304)

Ancestral genomes, sex, and the population structure of Trypanosoma cruzi. [PDF]

PLoS Pathogens, 2006
Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75 strains of the parasite with five nuclear microsatellite loci, 24Salpha RNA genes, and sequence ...
Jorge M de Freitas, Luiz Augusto-Pinto, Juliana R Pimenta, Luciana Bastos-Rodrigues, Vanessa F Gonçalves, Santuza M R Teixeira, Egler Chiari, Angela C V Junqueira, Octavio Fernandes, Andréa M Macedo, Carlos Renato Machado, Sérgio D J Pena   +11 more
doaj   +2 more sources

Trypanosoma cruzi-infected triatomines and rodents co-occur in a coastal island of northern Chile [PDF]

PeerJ, 2020
Trypanosoma cruzi, the cause agent of Chagas disease, is transmitted mainly by blood-feeding insects of the subfamily Triatominae. The T. cruzi life cycle alternates between triatomines and mammalian hosts, excluding birds and reptiles.
Ricardo Campos-Soto, Gabriel Díaz-Campusano, Nicol Quiroga, Catalina Muñoz-San Martín, Ninette Rives-Blanchard, Fernando Torres-Pérez   +5 more
doaj   +2 more sources

Characterization of Trypanosoma cruzi [PDF]

Memórias do Instituto Oswaldo Cruz, 1999
Departamento de Bioquimica e Imunologia, ICB-UFMG, 30270-010 Belo Horizonte, MG, Brasil *Laboratoriode Parasitologia Celular e Molecular, Centro de Pesquisas Rene Rachou-Fiocruz, Av. Augusto de Lima 1715,30190-002, Belo Horizonte, MG, BrasilKey words: Trypanosoma cruzi - genetic variation - populational ...
Silvane M. F. Murta, Silvane M. F. Murta, Alvaro J. Romanha   +2 more
openaire   +5 more sources

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. [PDF]

PLoS Pathogens, 2009
Host defense against the intracellular protozoan parasite Trypanosoma cruzi depends on Toll-like receptor (TLR)-dependent innate immune responses. Recent studies also suggest the presence of TLR-independent responses to several microorganisms, such as ...
Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda   +11 more
doaj   +1 more source

Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Chagas disease is the highest impact parasitic disease in Latin America. We have proposed that changes in Trypanosoma cruzi-specific immune responses might serve as surrogate indicators of treatment success. Herein, we addressed in a long-term
María G Alvarez, Graciela L Bertocchi, Gretchen Cooley, María C Albareda, Rodolfo Viotti, Damián E Perez-Mazliah, Bruno Lococo, Melisa Castro Eiro, Susana A Laucella, Rick L Tarleton   +9 more
doaj   +1 more source

Quantification of Trypanosoma cruzi in Tissue and Trypanosoma cruzi Killing Assay [PDF]

BIO-PROTOCOL, 2017
Infection with Trypanosoma cruzi causes Chagas disease. The methods provided here allow for the quantification of T. cruzi in the liver, heart, and blood of intraperitoneally-infected mice and analysis of the killing activity of the cells infected with T. cruzi in vitro.
Kiyoshi Takeda, Hisako Kayama, Shoko Kitada   +2 more
openaire   +4 more sources

The N-myristoylome of Trypanosoma cruzi [PDF]

Scientific Reports, 2016
AbstractProtein N-myristoylation is catalysed by N-myristoyltransferase (NMT), an essential and druggable target in Trypanosoma cruzi, the causative agent of Chagas’ disease. Here we have employed whole cell labelling with azidomyristic acid and click chemistry to identify N-myristoylated proteins in different life cycle stages of the parasite.
Roberts, Adam J., Fairlamb, Alan
openaire   +4 more sources

Trypanosoma cruzi: ancestral genomes and population structure

Memorias do Instituto Oswaldo Cruz, 2009
Although the genome of Trypanosoma cruzi has been completely sequenced, little is known about its population structure and evolution. Since 1999, two major evolutionary lineages presenting distinct epidemiological characteristics have been recognised: T.
Sérgio DJ Pena, Carlos Renato Machado, Andréa Mara Macedo   +2 more
doaj   +1 more source

Genomic comparison of Trypanosoma conorhini and Trypanosoma rangeli to Trypanosoma cruzi strains of high and low virulence

BMC Genomics, 2018
Background Trypanosoma conorhini and Trypanosoma rangeli, like Trypanosoma cruzi, are kinetoplastid protist parasites of mammals displaying divergent hosts, geographic ranges and lifestyles. Largely nonpathogenic T. rangeli and T.
Katie R Bradwell, Vishal N Koparde, Andrey V Matveyev, Myrna G Serrano, João M P Alves, Hardik Parikh, Bernice Huang, Vladimir Lee, Oneida Espinosa-Alvarez, Paola A Ortiz, André G Costa-Martins, Marta M G Teixeira, Gregory A Buck   +12 more
doaj   +1 more source

High Trypanosoma spp. diversity is maintained by bats and triatomines in Espírito Santo state, Brazil [PDF]

, 2017
The aim of this study was to reevaluate the ecology of an area in the Atlantic Forest, southeast Brazil, where Chagas disease (CD) has been found to occur.
Costa, Leonora Pires, Costa, Luciana M., Dario, Maria Augusta, Jansen, Ana Maria, Leite, Yuri Luiz Reis, Lisboa, Cristiane Varella, Llewellyn, Martin S., Moratelli, Ricardo, Nascimento, Monique Pereira, Roque, André Luiz Rodrigues, Xavier, Samanta Cristina das Chagas   +10 more
core   +2 more sources