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T6SS-mediated bacterial antagonism in the classroom
The study of bacterial antagonism, and specifically Type VI secretion System (T6SS)-mediated antagonism, has gained momentum over the last decade in research laboratories across the world. The T6SS is a molecular machine that mediates interbacterial antagonism as well as interactions with the host in the case of pathogenic or commensal organisms. Here,
Alejandro Tejada-Arranz +3 more
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Putative model for the Francisella T6SS.
, 2016 The model was adapted from [13]. The Francisella T6SS is presented in the contraction phase. While the interaction of IglF and IglG was demonstrated in this study, the function and the localization of IglF within the T6SS remain to be determined.
Jeanette E. Bröms (117821) +14 more
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The T6SS of EHEC does not show antibacterial activity in vitro.
, 2017 (A) The positive control of competition assays. A. baylyi ADP1 was used as a prey strain to be killed by the predator strains (P. aeruginosa PAO1, ΔretS or ΔppkA). The predator strains were individually mixed with A.
Jun Li (6494) +13 more
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Genetic organizations of T6SS in Serratia and other bacteria.
, 2015 (A), (B), (C) and (D) show the genetic organizations of the 11 T6SS clusters found in Serratia, which have different organizations and separate into four families (T6SS-a, T6SS-b, T6SS-c and T6SS-d). T6SS-a was aligned across S.
Amy H. Y. Kwok (452726) +6 more
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BMC Genomics, 2009 Background The availability of hundreds of bacterial genomes allowed a comparative genomic study of the Type VI Secretion System (T6SS), recently discovered as being involved in pathogenesis.
Vandenbrouck Yves +4 more
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Evolutionary Constraints of Defense Against T6SS Attack in E. Coli [PDF]
The Type VI secretion system (T6SS) is a toxin-tipped molecular spear used by Gram-negative bacteria to eliminate competitors in the environment. While the structure and function of the T6SS are well understood, less is known about how targeted bacteria ...
MacGillivray, Kathryn A., PhD
core
OmpR does not regulate the other Y. pseudotuberculosis T6SS loci.
, 2013 β-galactosidase activities (upper panel, in Miller units) and fluorescence levels (lower panel, in arbitrary units) of Y. pseudotuberculosis with lacZ and gfp fusions to T6SS-1, T6SS-2, T6SS-3-rev, T6SS-3-fwd, T6SS-4, T6SS-5 and vgrG (IP31758_0696 ...
Erwan Gueguen (423616) +5 more
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The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology [PDF]
, 2019 The type VI secretion system (T6SS) is crucialin interbacterial competition and is avirulence determinant ofmany Gram-negative bacteria. Several T6SS effectorsarecovalently fused to secreted T6SS structural components such asthe VgrG spike for
Bullen, NP +12 more
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Confirmed and Potential Roles of Bacterial T6SSs in the Intestinal Ecosystem
Frontiers in Microbiology, 2019 The contact-dependent type VI secretion system (T6SS) in diverse microbes plays crucial roles in both inter-bacterial and bacteria-host interactions.
Can Chen, Xiaobing Yang, Xihui Shen
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Model of ExoR-ChvG/ChvI-induced T6SS activation via acidity.
, 2012 (A) In neutral pH, ExoR associates with transmembrane sensor kinase ChvG and represses the ChvG/ChvI two-component system signaling, thus leading to reduced T6SS expression and secretion activity.
Chih-Feng Wu (117145) +3 more
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