Results 1 to 10 of about 28,167,766 (413)

In vitro maturation of human pluripotent stem cell-derived cardiomyocyte: A promising approach for cell therapy

open access: yesJournal of Animal Reproduction and Biotechnology, 2022
Currently, there is no treatment to reverse or cure heart failure caused by ischemic heart disease and myocardial infarction despite the remarkable advances in modern medicine.
Yun-Gwi Park   +3 more
doaj   +1 more source

Novel microRNAs modulating ecto-5′-nucleotidase expression

open access: yesFrontiers in Immunology, 2023
IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape.
Theresa Kordaß   +4 more
doaj   +1 more source

The role of antigen-competitive dynamics in regulating the immune response [PDF]

open access: yesBulletin of Mathematical Biology, 83(5): 40 (2021), 2021
The clonal expansion of T cells during an infection is tightly regulated to ensure an appropriate immune response against invading pathogens. Although experiments have mapped the trajectory from expansion to contraction, the interplay between mechanisms that control this response are not fully understood.
arxiv   +1 more source

Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC

open access: yesScientific Reports, 2022
The differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes.
Hideyuki Hiyoshi   +10 more
doaj   +1 more source

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

open access: yesNature Communications, 2021
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of ...
Kenji Miki   +20 more
doaj   +1 more source

Real-time stain-free classification of cancer cells and blood cells using interferometric phase microscopy and machine learning [PDF]

open access: yesCytometry A 99: 511-523, 2021, 2021
We present a method for a real time visualization and automatic processing for detection and classification of untouched cancer cells in blood during stain free imaging flow cytometry using digital holographic microscopy and machine learning in throughput of 15 cells per second.
arxiv   +1 more source

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

open access: yesNature Communications, 2021
T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor ...
Shoichi Iriguchi   +19 more
doaj   +1 more source

Cells, Cells, and More Cells

open access: yesSurvey of Ophthalmology, 2007
A 64-year-old woman presented with bilateral optic nerve swelling, vitreous cells, and cerebrospinal fluid monocytic pleocytosis. A chest radiograph and computed tomography demonstrated a lesion in the left lung, which histologically was confirmed to be a small-cell lung carcinoma.
Departments of Ophthalmology and Medicine (Division of Neurology), Duke University Eye Center and Duke University Medical Center, Durham, North Carolina ( host institution )   +4 more
openaire   +4 more sources

Cells, Stem Cells, and Cancer Stem Cells [PDF]

open access: yesSeminars in Reproductive Medicine, 2013
The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Carlos Simón   +1 more
openaire   +4 more sources

Axicabtagene Ciloleucel CAR T‐Cell Therapy in Refractory Large B‐Cell Lymphoma

open access: yesNew England Journal of Medicine, 2017
Background In a phase 1 trial, axicabtagene ciloleucel (axi‐cel), an autologous anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy, showed efficacy in patients with refractory large B‐cell lymphoma after the failure of conventional therapy. Methods
S. Neelapu   +39 more
semanticscholar   +1 more source

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