Journal of Animal Reproduction and Biotechnology, 2022 Currently, there is no treatment to reverse or cure heart failure caused by ischemic heart disease and myocardial infarction despite the remarkable advances in modern medicine.
Yun-Gwi Park +3 more
doaj +1 more source
Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K +6 more
core +9 more sources
Novel microRNAs modulating ecto-5′-nucleotidase expression
Frontiers in Immunology, 2023 IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape.
Theresa Kordaß +4 more
doaj +1 more source
The role of antigen-competitive dynamics in regulating the immune response [PDF]
Bulletin of Mathematical Biology, 83(5): 40 (2021), 2021 The clonal expansion of T cells during an infection is tightly regulated to ensure an appropriate immune response against invading pathogens. Although experiments have mapped the trajectory from expansion to contraction, the interplay between mechanisms that control this response are not fully understood.
arxiv +1 more source
Scientific Reports, 2022 The differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes.
Hideyuki Hiyoshi +10 more
doaj +1 more source
ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
Nature Communications, 2021 Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of ...
Kenji Miki +20 more
doaj +1 more source
Nature Communications, 2021 T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor ...
Shoichi Iriguchi +19 more
doaj +1 more source
Real-time stain-free classification of cancer cells and blood cells using interferometric phase microscopy and machine learning [PDF]
Cytometry A 99: 511-523, 2021, 2021 We present a method for a real time visualization and automatic processing for detection and classification of untouched cancer cells in blood during stain free imaging flow cytometry using digital holographic microscopy and machine learning in throughput of 15 cells per second.
arxiv +1 more source
The tax-inducible actin-bundling protein fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1) [PDF]
, 2016 The delta-retrovirus Human T-cell leukemia virus type 1 (HTLV-1) preferentially infects CD4(+) T-cells via cell-to-cell transmission. Viruses are transmitted by polarized budding and by transfer of viral biofilms at the virological synapse (VS ...
Gettemans, Jan +6 more
core +15 more sources
T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. [PDF]
, 2017 T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Coles, Marc +10 more
core +6 more sources