Results 1 to 10 of about 29,027,932 (385)
Journal of Animal Reproduction and Biotechnology, 2022 Currently, there is no treatment to reverse or cure heart failure caused by ischemic heart disease and myocardial infarction despite the remarkable advances in modern medicine.
Yun-Gwi Park +3 more
doaj +1 more source
CAR-T cell therapy: current limitations and potential strategies
Blood Cancer Journal, 2021 Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. Although treatment with CAR-T cells has produced remarkable clinical responses with certain subsets of B cell leukemia or lymphoma, many challenges limit ...
Robert C. Sterner, Rosalie M. Sterner
semanticscholar +1 more source
Long-term outcomes following CAR T cell therapy: what we know so far
Nature Reviews Clinical Oncology, 2023 Chimeric antigen receptors (CAR) are engineered fusion proteins designed to target T cells to antigens expressed on cancer cells. CAR T cells are now an established treatment for patients with relapsed and/or refractory B cell lymphomas, B cell acute ...
Kathryn M. Cappell, J. Kochenderfer
semanticscholar +1 more source
Novel microRNAs modulating ecto-5′-nucleotidase expression
Frontiers in Immunology, 2023 IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape.
Theresa Kordaß +4 more
doaj +1 more source
A guide to cancer immunotherapy: from T cell basic science to clinical practice
Nature reviews. Immunology, 2020 The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against cancer.
A. Waldman, Jill M. Fritz, M. Lenardo
semanticscholar +1 more source
Scientific Reports, 2022 The differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes.
Hideyuki Hiyoshi +10 more
doaj +1 more source
ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
Nature Communications, 2021 Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of ...
Kenji Miki +20 more
doaj +1 more source
Nature Communications, 2021 T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor ...
Shoichi Iriguchi +19 more
doaj +1 more source
Survey of Ophthalmology, 2007 A 64-year-old woman presented with bilateral optic nerve swelling, vitreous cells, and cerebrospinal fluid monocytic pleocytosis. A chest radiograph and computed tomography demonstrated a lesion in the left lung, which histologically was confirmed to be a small-cell lung carcinoma.
Departments of Ophthalmology and Medicine (Division of Neurology), Duke University Eye Center and Duke University Medical Center, Durham, North Carolina ( host institution ) +4 more
openaire +4 more sources
Cells, Stem Cells, and Cancer Stem Cells [PDF]
Seminars in Reproductive Medicine, 2013 The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Carlos Simón +1 more
openaire +4 more sources