Results 11 to 20 of about 8,713,756 (356)

Downregulation of HMGB1 in thymoma cells affects T cell differentiation

Central European Journal of Immunology, 2023
Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma
Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang   +5 more
doaj   +1 more source

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C, Freeman, Tom, Hasegawa, Hitoshi, Herbert, Mark, McMichael, Andrew J, Willinger, Tim   +5 more
core   +1 more source

Chronic Inflammation Links Cancer and Parkinson’s disease

Frontiers in Aging Neuroscience, 2016
An increasing number of genetic studies suggest that the pathogenesis of Parkinson’s disease (PD) and cancer share common genes, pathways, and mechanisms.
Zhiming eLi, Zhiming eLi, Zaozao eZheng, Zaozao eZheng, Jun eRuan, Jun eRuan, Zhi eLi, Zhi eLi, Chi-Meng eTzeng, Chi-Meng eTzeng, Chi-Meng eTzeng   +10 more
doaj   +1 more source

Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]

, 1993
Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL, Phillips, JH, Spits, H, Sánchez, MJ   +3 more
core   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source

T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

Cell Reports, 2020
Summary: T cell factor 1 (Tcf1) promotes the central memory CD8+ T (TCM) cell differentiation and stemness in lymphoid tissues after systemic infections.
Jingxia Wu, Alaa Madi, Alessa Mieg, Agnes Hotz-Wagenblatt, Nina Weisshaar, Sicong Ma, Kerstin Mohr, Tilo Schlimbach, Marvin Hering, Helena Borgers, Guoliang Cui   +10 more
doaj   +1 more source

Ex-vivo CS1-OKT3 dual specific bivalent antibody-armed effector T cells mediate cellular immunity against multiple myeloma

Scientific Reports, 2023
Bispecific T cell engaging antibodies (bsAbs) have emerged as novel and powerful therapeutic agents for redirecting T cells towards antigen-specific tumor killing.
Dennis Awuah, Lin Li, Lindsay Williams, Ryan Urak, Maciej Kujawski, Stephen J. Forman, John E. Shively, Xiuli Wang   +7 more
doaj   +1 more source

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu, A Kadioglu, A Nalbant, A Strasser, AD Badley, Andrea M. Mitchell, C Riccardi, CA Janeway Jr, CK Sung, D Zhou, David H. Dockrell, DH Dockrell, DH Dockrell, DH Dockrell, DR Cundell, EE McGrath, FK Swirski, Frank R. DeLeo, G Matute-Bello, Helen M. Marriott, HM Marriott, HM Marriott, I Nicoletti, J Warwick-Davies, JA Carrero, Julie A. Preston, K Beiter, K Kemp, K LeMessurier, KA Browne, KE Price, L Galluzzi, L Maggi, L Ziegler-Heitbrock, LA Kirkham, M Daigneault, M Lenardo, M Witzenrath, MA Barocchi, MA Bewley, Marc Daigneault, Martin A. Bewley, MJ Jedrzejas, Moira K. B. Whyte, N Olivares-Zavaleta, N Oyaizu, NV Serbina, PA Kiener, R Malley, RA Hirst, Robert C. Read, RS Hotchkiss, RS Hotchkiss, RS Hotchkiss, SE Weber, SJ Webster, SL Newman, T Mattern, T Takahashi, Thushan I. De Silva, Timothy J. Mitchell, WL Farrar, WP Hausdorff, YJ Lu, Z Zhang   +64 more
core   +4 more sources

A novel CCM2 gene mutation associated with family cerebral cavernous malformation

Frontiers in Aging Neuroscience, 2016
Background: Cerebral cavernous malformations (CCMs) are common vascular malformations that predominantly arise in the central nervous system and are mainly characterized by enlarged vascular cavities without intervening brain parenchyma.
Wen-Qing Huang, Wen-Qing Huang, Cong-Xia Lu, Ya Zhang, Ya Zhang, Ke-Hui Yi, Liang-Liang Cai, Liang-Liang Cai, Ming-Li Li, Ming-Li Li, Han Wang, Han Wang, Qing Lin, Qing Lin, Chi-Meng Tzeng, Chi-Meng Tzeng, Chi-Meng Tzeng   +16 more
doaj   +1 more source

Cytotoxic T Cells [PDF]

Journal of Investigative Dermatology, 2006
The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Andersen, Mads Hald, Schrama, David, thor Straten, Per, Becker, Jürgen C.   +3 more
openaire   +2 more sources