Results 11 to 20 of about 3,899,518 (170)

A novel CCM2 gene mutation associated with family cerebral cavernous malformation

Frontiers in Aging Neuroscience, 2016
Background: Cerebral cavernous malformations (CCMs) are common vascular malformations that predominantly arise in the central nervous system and are mainly characterized by enlarged vascular cavities without intervening brain parenchyma.
Wen-Qing Huang, Wen-Qing Huang, Cong-Xia Lu, Ya Zhang, Ya Zhang, Ke-Hui Yi, Liang-Liang Cai, Liang-Liang Cai, Ming-Li Li, Ming-Li Li, Han Wang, Han Wang, Qing Lin, Qing Lin, Chi-Meng Tzeng, Chi-Meng Tzeng, Chi-Meng Tzeng   +16 more
doaj   +1 more source

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

Nature Communications, 2021
The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear.
Cécile Gaston, Simon De Beco, Bryant Doss, Meng Pan, Estelle Gauquelin, Joseph D’Alessandro, Chwee Teck Lim, Benoit Ladoux, Delphine Delacour   +8 more
doaj   +1 more source

Cytotoxic T Cells [PDF]

Journal of Investigative Dermatology, 2006
The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Andersen, Mads Hald, Schrama, David, thor Straten, Per, Becker, Jürgen C.   +3 more
openaire   +2 more sources

Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E

Frontiers in Immunology, 2018
The NT5E (CD73) molecule represents an ecto-5′-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in ...
Theresa Kordaß, Theresa Kordaß, Wolfram Osen, Stefan B. Eichmüller   +3 more
doaj   +1 more source

Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

Nature Communications, 2019
The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti, Laurence Bataille, Jean-Marie Carpier, Stéphanie Dogniaux, Mabel San Roman-Jouve, Mathieu Maurin, Michael W. Stuck, Rosa M. Rios, Cosima T. Baldari, Gregory J. Pazour, Claire Hivroz   +10 more
doaj   +1 more source

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

Frontiers in Immunology, 2019
Recent immunotherapeutic approaches using adoptive cell therapy, or checkpoint blockade, have demonstrated the powerful anti-cancer potential of CD8 cytotoxic T-lymphocytes (CTL).
Sarah A. E. Galloway, Garry Dolton, Meriem Attaf, Aaron Wall, Anna Fuller, Cristina Rius, Valentina Bianchi, Sarah Theaker, Angharad Lloyd, Angharad Lloyd, Marine E. Caillaud, Inge Marie Svane, Marco Donia, David K. Cole, David K. Cole, Barbara Szomolay, Pierre Rizkallah, Andrew K. Sewell, Andrew K. Sewell   +18 more
doaj   +1 more source

Challenging perspectives on the cellular origins of lymphoma [PDF]

Open Biology, 2016
Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon
Tim I. M. Malcolm, Daniel J. Hodson, Elizabeth A. Macintyre, Suzanne D. Turner   +3 more
doaj   +1 more source

MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo

OncoImmunology
There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited.
Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya, Barbara Fazekas de St Groth   +4 more
doaj   +1 more source

T Cell Hybrids with T Cell Functions

, 1979
Different T cell functions, e.g. help, suppression and cytotoxicity are associated with different T cell subsets, bearing distinctive differentiation markers. Thus effector T cells mediating help are Ly 1+2−3− and may bear Ia determinants, those mediating suppression are Ly 1−2+3+, IJ+, and cytotoxic cells are Ly 1−2+3+ and do not bear Ia determinants (
Simpson, E, Kontiainen, S, Herzenberg, L, Bohrer, E, Torano, A, Vogt, P, Beverley, P, Fitzpatrick, W, Feldmann, M   +8 more
openaire   +3 more sources

Combination therapy with PD-1 blockade and radiofrequency ablation for recurrent hepatocellular carcinoma: a propensity score matching analysis

International Journal of Hyperthermia, 2021
Background This study aimed to evaluate whether combined therapy with PD-1 blockade (anti-PD-1) and radiofrequency ablation (RFA) is superior to RFA monotherapy for recurrent hepatocellular carcinoma (HCC).
Xiaofei Wang, Guo Liu, Shu Chen, Huaqiang Bi, Feng Xia, Kai Feng, Kuansheng Ma, Bing Ni   +7 more
doaj   +1 more source