Results 251 to 260 of about 8,198,133 (306)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling. [PDF]

N Engl J Med
Ye P, Bergerson JRE, Brownell I, Starrett GJ, Abraham RS, Anderson MV, Martin T, MacMath D, Kuehn HS, Padiadpu J, Zhao S, Rosenzweig SD, Tussiwand R, Leonard WJ, Pittaluga S, Raffeld M, Arnold DE, Lisco A.   +17 more
europepmc   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Prior chemotherapy deteriorates T-cell quality for CAR T-cell therapy in B-cell non-Hodgkin's lymphoma. [PDF]

J Immunother Cancer
Junkuhn C, Schiele P, Walter AL, Hamm F, Obermayer B, Busch D, Stroux A, Frick M, Penack O, Damm F, Polansky J, Bullinger L, Künkele A, Frentsch M, Na IK.   +14 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Predicting Mechanosensitive T Cell Expansion from Cell Spreading. [PDF]

Adv Healthc Mater
Wang X, Xu R, Hu S, Sun D, Guo J, Lamanna N, Kam LC.   +6 more
europepmc   +1 more source

The T cell receptor sequence influences the likelihood of T cell memory formation. [PDF]

Cell Rep
Lagattuta KA, Kohlgruber AC, Abdelfattah NS, Nathan A, Rumker L, Birnbaum ME, Elledge SJ, Raychaudhuri S.   +7 more
europepmc   +1 more source

T cell-derived small extracellular vesicles in cancer-immune interactions. [PDF]

Cancer Immunol Immunother
Garcia MJC, Hnit SST, Shklovskaya E, Wang Y.   +3 more
europepmc   +1 more source

A dual nature of γδ T cell immune memory responses. [PDF]

Elife
Suen TK, Al B, Scarpa A, Dorhoi A, Netea MG, Placek K.   +5 more
europepmc   +1 more source

T Cell Resistance: On the Mechanisms of T Cell Non-activation. [PDF]

Immune Netw
Beckers D, Jainarayanan AK, Dustin ML, Capera J.   +3 more
europepmc   +1 more source