Scientific Reports, 2023 Bispecific T cell engaging antibodies (bsAbs) have emerged as novel and powerful therapeutic agents for redirecting T cells towards antigen-specific tumor killing.
Dennis Awuah +7 more
doaj +1 more source
Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]
, 2012 Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu +64 more
core +4 more sources
Metabolic regulation of regulatory T cell development and function [PDF]
, 2014 It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves +68 more
core +6 more sources
Downregulation of HMGB1 in thymoma cells affects T cell differentiation
Central European Journal of Immunology, 2023 Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma
Jian Li +5 more
doaj +1 more source
Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]
, 2006 The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C +5 more
core +1 more source
Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]
, 2015 Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
core +1 more source
EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
Nature Communications, 2021 The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear.
Cécile Gaston +8 more
doaj +1 more source
Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E
Frontiers in Immunology, 2018 The NT5E (CD73) molecule represents an ecto-5′-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in ...
Theresa Kordaß +3 more
doaj +1 more source
MicroRNAs affecting the susceptibility of melanoma cells to CD8+ T cell‐mediated cytolysis
Clinical and Translational Medicine, 2023 Background The regulatory functions of microRNAs (miRNAs) in anti‐tumour immunity have been mainly described in immune effector cells. Since little is known about miRNA effects on the susceptibility of target cells during T cell—target cell interaction ...
Antonino A. Pane +8 more
doaj +1 more source
Cell-in-cell: A virgin land of cell biology [PDF]
OncoImmunology, 2013 Cell-in-cell affects multiple functions of both internalized and internalizing cells. Immune effector cells and their targets can also interact in this fashion. We have recently investigated the outcome of cell-in-cell, the molecular mechanisms underpinning this phenomenon, and its relevance in both physiological and pathological conditions.
Ying Wang, Xiaoning Wang
openaire +3 more sources