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Mechanoimmunology of T‐Cell Activation
Scandinavian Journal of ImmunologyABSTRACTT‐cell activation, a pivotal process in the adaptive immune response, is initiated when the T cell receptor (TCR) recognises and binds to antigenic peptide‐major histocompatibility complex (pMHC) molecules on the cell membrane. Emerging evidence indicates that mechanical cues regulate T‐cell activation by modulating TCR signalling and ...
Xuelan Wu, Zhiyi Ye
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Macrophage activation by T cells
Current Opinion in Immunology, 1992In the past year, the application of biochemical and molecular approaches to the analysis of macrophage activation by T cells has provided new information concerning the regulation of gene expression during the activation process, and advanced our understanding of the multiple mechanisms that influence the development of macrophage function during an ...
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Science's STKE, 2005
Transcription factors activated in response to T cell receptor (TCR) signaling include nuclear factor of activated T cells (NFAT) family, which is highly phosphorylated and thereby maintained in the cytoplasm of resting T cells, the nuclear factor NF-κB, which is kept in the cytoplasm of resting cells through its association with the inhibitor protein ...
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Transcription factors activated in response to T cell receptor (TCR) signaling include nuclear factor of activated T cells (NFAT) family, which is highly phosphorylated and thereby maintained in the cytoplasm of resting T cells, the nuclear factor NF-κB, which is kept in the cytoplasm of resting cells through its association with the inhibitor protein ...
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T Cell\-Dependent B Cell Activation
Annual Review of Immunology, 1993B cells obtain help from T cells in the antibody response by acting as antigen-specific antigen presenting cells. A direct signal through binding of antigen to membrane Ig can enhance B cell antigen presentation and T-dependent B cell activation, but is not required for a productive interaction between a small resting B cell and a differentiated helper
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T-Cell Regulation: Tails of phosphorylation and T-cell activation
Current Biology, 1994How do quantitative differences in T-cell signal transduction lead to qualitatively different responses? Recent work demonstrates that even well-established regulatory paradigms are open to question.
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T cell activation deficiencies
Clinical Immunology and Immunopathology, 1995F, Le Deist +7 more
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Critical care management of chimeric antigen receptor T-cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
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