Results 231 to 240 of about 1,940,376 (313)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation. [PDF]

Nat Commun
Stötzel I, Weier AK, Sarkar A, Som S, Bach L, Konopka P, Miková E, Ghosh S, Böthling J, Homrich M, Schaedel L, Kazmaier U, Symeonidis K, Ebner S, Weidner P, Abdullah Z, Meissner F, Uderhardt S, Hons M, Baumjohann D, Paul R, Rieger H, Kiermaier E.   +22 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A primer on tRNAs, tRNA-m¹A58 modification, and tRNA derivatives in T-cell activation. [PDF]

Front Cell Dev Biol
Zhao C, Shen J.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

CD1a and Lipids as Mediators of T Cell Activation in the Skin. [PDF]

J Invest Dermatol
Fahmy LM, Adeuyan OO, de Jong A.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation. [PDF]

FEBS Open Bio
Ortega-Francisco S, Olguín-Alor R, Bolaños-Castro L, Morales-Cruz A, De La Fuente-Granada M, Soldevila G.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation. [PDF]

Sci Adv
Wang Z, Dong W, Feng X, Xu X, An Y, Xiao H, Luo M, Liang Q, Bai R, Zhao K, Wu L, Zhao L, Zhou Y, Yi X, Huang D, Sengupta K, Plewczynski D, Sham PC, Liu C, Yu Y, Li W, Gong Q, Song W, Zhou W, Li MJ.   +24 more
europepmc   +1 more source