Results 271 to 280 of about 1,940,376 (313)
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Science's STKE, 2005
Transcription factors activated in response to T cell receptor (TCR) signaling include nuclear factor of activated T cells (NFAT) family, which is highly phosphorylated and thereby maintained in the cytoplasm of resting T cells, the nuclear factor NF-κB, which is kept in the cytoplasm of resting cells through its association with the inhibitor protein ...
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Transcription factors activated in response to T cell receptor (TCR) signaling include nuclear factor of activated T cells (NFAT) family, which is highly phosphorylated and thereby maintained in the cytoplasm of resting T cells, the nuclear factor NF-κB, which is kept in the cytoplasm of resting cells through its association with the inhibitor protein ...
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Mechanoimmunology of T‐Cell Activation
Scandinavian Journal of ImmunologyABSTRACTT‐cell activation, a pivotal process in the adaptive immune response, is initiated when the T cell receptor (TCR) recognises and binds to antigenic peptide‐major histocompatibility complex (pMHC) molecules on the cell membrane. Emerging evidence indicates that mechanical cues regulate T‐cell activation by modulating TCR signalling and ...
Xuelan Wu, Zhiyi Ye
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Immunological Reviews, 2003
Summary: Guanine nucleotide binding proteins rapidly cycle between a guanosine diphosphate (GDP)‐bound and guanosine triphosphate (GTP)‐bound state, and they operate as binary switches that control cell activation in response to environmental cues. GTPases adopt different conformations when binding GTP vs. GDP.
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Summary: Guanine nucleotide binding proteins rapidly cycle between a guanosine diphosphate (GDP)‐bound and guanosine triphosphate (GTP)‐bound state, and they operate as binary switches that control cell activation in response to environmental cues. GTPases adopt different conformations when binding GTP vs. GDP.
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T Cell\-Dependent B Cell Activation
Annual Review of Immunology, 1993B cells obtain help from T cells in the antibody response by acting as antigen-specific antigen presenting cells. A direct signal through binding of antigen to membrane Ig can enhance B cell antigen presentation and T-dependent B cell activation, but is not required for a productive interaction between a small resting B cell and a differentiated helper
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T-Cell Regulation: Tails of phosphorylation and T-cell activation
Current Biology, 1994How do quantitative differences in T-cell signal transduction lead to qualitatively different responses? Recent work demonstrates that even well-established regulatory paradigms are open to question.
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Activation‐induced cell death in T cells
Immunological Reviews, 2003Summary: A properly functioning immune system is dependent on programmed cell death at virtually every stage of lymphocyte development and activity. This review addresses the phenomenon of activation‐induced cell death (AICD) in T lymphocytes, in which activation through the T‐cell receptor results in apoptosis.
Douglas R, Green +2 more
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The role of dendritic cells in T cell activation
Immunology & Cell Biology, 1997Dendritic cells (DC) are distinguishable from other antigen‐presenting cells by their potent antigen‐presenting capacity. They are not only efficient at presenting peptide antigen but can also process and present soluble protein antigens to antigen‐specific T cells and cloned T cell lines.
K, Ni, H C, O'Neill
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T-cell-mediated activation of B cells
Current Opinion in Immunology, 1991Antibody responses to protein antigens are dependent on helper T lymphocytes, which provide necessary growth and differentiation, inducing stimuli to antigen-specific B cells. Recent investigations have focused on the mechanisms of T-B interactions, and the nature of the T-cell-derived signals that are needed for activation and expansion of B cells.
H J, Burstein, A K, Abbas
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T Cell‐Dependent B Cell Activation
Immunological Reviews, 1984T cell-dependent induction of small, resting B lymphocytes requires direct recognition of antigen and/or I-A/E molecules on the B cell surface by the inducing helper cell, and it does not require the participation of Ig receptors on the responding B cell.
A, Coutinho +7 more
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Cell Biology of T Cell Activation and Differentiation
2006T cells are major components of the adaptive immune system. They can differentiate into two different populations of effector cells-type one and type two-and may also become tolerant. T cells respond to immune challenges by interacting with antigen-presenting cells of the innate immune system.
María Angélica, Santana +1 more
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