Results 241 to 250 of about 30,095,077 (303)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Sex-biased human thymic architecture guides T cell development through spatially defined niches. [PDF]

Dev Cell
Stankiewicz LN, Salim K, Flaschner EA, Wang YX, Edgar JM, Durland LJ, Lin BZB, Bingham GC, Major MC, Jones RD, Blau HM, Rideout EJ, Levings MK, Zandstra PW, Rossi FMV.   +14 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Peripheral T Cell Development and Immunophenotyping of Twins with Heterozygous FOXN1 Mutations. [PDF]

Immunohorizons
Voss K, Bartkowiak T, Sewell AE, Chi C, Landis MD, Schaefer S, Pua HH, Connelly JA, Irish JM, Rathmell JC, Kaviany S.   +10 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluating in vivo approaches for studying the roles of thymic DCs in T cell development in mice. [PDF]

Front Immunol
Wang Y, Chong MMW.
europepmc   +1 more source

Effects of vitamin D supplementation on T cell activation and regulatory T cell development in <i>Ldlr</i> ^-/- mice. [PDF]

Nutr Res Pract
Lee Y, Nam D, Yoo S, Choi WY, Lu Y, Lee GY, Shin H, Han SN.   +7 more
europepmc   +1 more source

Mechanism study of ubiquitination in T cell development and autoimmune disease. [PDF]

Front Immunol
Yu H, Yang W, Cao M, Lei Q, Yuan R, Xu H, Cui Y, Chen X, Su X, Zhuo H, Lin L.   +10 more
europepmc   +1 more source

BAFF promotes follicular helper T cell development and germinal center formation through BR3 signal. [PDF]

JCI Insight
Chen Y, Chen M, Liu Y, Li Q, Xue Y, Liu L, Liang R, Xiong Y, Zhao J, Chen J, Lin W, Wang J, Pan YF, Stohl W, Zheng SG.   +14 more
europepmc   +1 more source

Restoration of thymic T-cell development by bone marrow transplantation in mouse radiation lymphomagenesis. [PDF]

J Radiat Res
Takeshima T, Hasegawa S.
europepmc   +1 more source