Results 261 to 270 of about 30,095,077 (303)
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B cell‐dependent T cell development
Acta Paediatrica, 2004T and B cells are thought to develop independently. While it is widely recognized that T cells help B cells in the production of antibodies to protein antigens, less well understood is whether or how B cells contribute to T cell development and function.
M, Cascalho, J L, Platt
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Glucocorticoids in T Cell Development and Function
Annual Review of Immunology, 2000Glucocorticoids are small lipophilic compounds that mediate their many biological effects by binding an intracellular receptor (GR) that, in turn, translocates to the nucleus and directly or indirectly regulates gene transcription. Perhaps the most recognized biologic effect of glucocorticoids on peripheral T cells is immunosuppression, which is due to
J D, Ashwell, F W, Lu, M S, Vacchio
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T Cell Development and T Cell Receptor Structure
2021B and T lymphocytes differentiate from the common lymphoid progenitor in the bone marrow. While B cells develop in the bone marrow, thymocytes differentiated from the common lymphoid progenitor migrate from the bone marrow into the thymus, and enter the cortex of the thymus from blood vessels located in the corticomedullary junction.
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T‐cell development, doing it in a dish
Immunological Reviews, 2006Summary: The thymus provides a unique environment for the development of T lymphocytes from bone marrow‐derived progenitor cells. Several environmental factors have been identified that influence the development of T cells in the thymus. In particular, the Notch pathway has emerged as critical for the induction of T‐lineage commitment and ...
Thomas M, Schmitt +1 more
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T‐cell development: an extrathymic perspective
Immunological Reviews, 2006Summary: The lymph nodes (LNs) harbor a cryptic T‐lymphopoietic pathway that is dramatically amplified by oncostatin M (OM). OM‐transgenic mice generate massive amounts of T lymphocytes in the absence of Lin–c‐KithiIL‐7Rα– lymphoid progenitors and of reticular epithelial cells.
Marie-Eve, Blais +2 more
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T Cell Development in the Fetus and Neonate
1991T lymphocytes (T cells) play a central role in the immune response acting both to mediate specific immune functions and to modulate the function of all other aspects of the immune system. T cells mediate these effects both through direct cell-cell interactions and through the production of soluble mediators known as lymphokines.
C B, Wilson, D B, Lewis, B K, English
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1987
The study of ontogeny of T cells or of any other function has three aspects: the descriptive timing of appearance since inception, the quantitative evaluation of cell numbers, and the functional studies to detect if early functions are qualitatively different from those of the adult (Stutman 1985).
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The study of ontogeny of T cells or of any other function has three aspects: the descriptive timing of appearance since inception, the quantitative evaluation of cell numbers, and the functional studies to detect if early functions are qualitatively different from those of the adult (Stutman 1985).
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T-cell development made simple
Nature Reviews Immunology, 2004The thymus is the primary site of T-cell lymphopoiesis. However, the precise molecular interactions that enable the thymus to carry out this function are only recently being elucidated. Although several important molecular players have been identified, including soluble factors, extracellular matrix components, and integral membrane receptors and their
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