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T Cell Development and Function [PDF]
Rejuvenation Research, 2023 T cells play critical roles in the immune system, including in responses to cancer, autoimmunity, and tissue regeneration. T cells arise from common lymphoid progenitors (CLPs) that differentiate from hematopoietic stem cells in the bone marrow. CLPs then traffic to the thymus, where they undergo thymopoiesis through a number of selection steps ...
Kwasi, Adu-Berchie +2 more
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T Cell Development by the Numbers
Trends in Immunology, 2017T cells are continually generated in the thymus in a highly dynamic process comprising discrete steps of lineage commitment, T cell receptor (TCR) gene rearrangement, and selection. These steps are linked to distinct rates of proliferation, survival, and cell death, but a quantitative picture of T cell development is only beginning to emerge.
Andreas, Krueger +2 more
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Annual Review of Immunology, 2020
Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
Peter A, Savage +2 more
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Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
Peter A, Savage +2 more
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Nature Methods, 2021
Artificial thymic organoid systems recapitulate murine thymopoiesis in vitro.
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Artificial thymic organoid systems recapitulate murine thymopoiesis in vitro.
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T Cell Receptors and T Cell Development
1996Birds provide a valuable model system for the study of early development. Studies of immune system development and function in chickens have contributed to some of the central tenets in immunology. These include:(1) allorecognition by lymphocytes in graft-vs-host (GVH) reactions (Simonsen 1985), (2) clonal reactivity of immunocompetent lymphocytes ...
C H, Chen +6 more
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A role for a pre-T-cell receptor in T-cell development
Immunology Today, 1993Expression of a productive T-cell receptor (TCR) beta gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCR beta-gene rearrangement. Here Marcus Groettrup and Harald von Boehmer discuss the data obtained in various experimental models and ...
M, Groettrup, H, von Boehmer
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T-cell development in the absence of the pre-T-cell receptor
Immunology Letters, 1997The development of pre-T-cells with productive T-cell receptor beta (TCR beta) rearrangements can be furthered by each of the pre-T-cell receptors (pre-TCR), the alpha beta TCR as well as the gamma delta TCR, albeit by distinct mechanisms. While the gamma delta TCR affects CD4-8- precursor cells irrespective of their TCR beta rearrangement status both ...
J, Buer +4 more
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In vitromodels of T cell development
Seminars in Immunology, 1999A number of in vitro systems are currently being used to study both thymocyte development and thymic stromal cell function. However, the usefulness of dispersed culture systems is limited since they often involve disruption of interactions within the normal three-dimensional architecture of the thymus in vivo which are critical for normal development ...
K J, Hare, E J, Jenkinson, G, Anderson
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2006
Abstract The purpose of this chapter is to give a broad overview of some of the complexities involved in T cell development. T cells are key regulators of specific immunity, and their function is determined by events that occur during an intricate developmental process in the thymus.
T MAK, M SAUNDERS
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Abstract The purpose of this chapter is to give a broad overview of some of the complexities involved in T cell development. T cells are key regulators of specific immunity, and their function is determined by events that occur during an intricate developmental process in the thymus.
T MAK, M SAUNDERS
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The Development of T-Cell Immunity
2010Publisher Summary This chapter presents an introduction to the book on the development of immunity. The book discusses the four main topics of T-cell immunity—namely, evolution of T-cell immunity, thymic requirements for T-cell immunity, T-cell immunity in the periphery, and prevention of T-cell-dependent autoimmunity.
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