Results 231 to 240 of about 2,651,718 (307)

Predicting the conformational flexibility of antibody and T cell receptor complementarity-determining regions. [PDF]

Nat Mach Intell
Spoendlin FC, Fernández-Quintero ML, Raghavan SSR, Turner HL, Gharpure A, Loeffler JR, Wong WK, Bujotzek A, Georges G, Ward AB, Deane CM.   +10 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

T cell receptor (TCR)-based therapy in advanced non-small cell lung cancer: a new hope? [PDF]

Transl Lung Cancer Res
Costantini A, Giroux Leprieur E.
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Distinct characteristics of T cell receptor repertoire associated with the SARS-CoV-2 reinfection. [PDF]

Front Immunol
Zeng L, Liu L, Ren B, Feng B, Lai X, Lai X, Chen Z, Huang Y, Hong W.   +8 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Circulating T-cell receptor repertoire for cancer early detection. [PDF]

NPJ Precis Oncol
Li Y, Nahas M, Stephens D, Froburg K, Hintz E, Champagne D, Lochab A, Brown M, Braun J, Fortuño MA, Ocón MD, Pasquier A, Luque-Vázquez I, Moudgalya H, Kivlehan S, Gjeci I, Korle SL, Campo A, Rodriguez M, Seder CW, Lizotte PH, Bueno R, Borgia JA, Seijo LM, Montuenga LM, Yelensky R.   +25 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Conditional generation of real antigen-specific T cell receptor sequences. [PDF]

Nat Mach Intell
Karthikeyan D, Bennett SN, Reynolds AG, Vincent BG, Rubinsteyn A.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source