Results 241 to 250 of about 2,651,718 (307)

The geometry of pMHC-coated nanoparticles and T-cell receptor clusters governs the sensitivity-specificity trade-off in T-cell response: a modeling investigation. [PDF]

Immunol Cell Biol
Richez L, Khadra A.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

T cell receptor specificity landscape revealed through de novo peptide design. [PDF]

Proc Natl Acad Sci U S A
Visani GM, Pun MN, Minervina AA, Bradley P, Thomas PG, Nourmohammad A.   +5 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Parallel reactions on a single T cell receptor offer a robust kinetic proofreading mechanism. [PDF]

Proc Natl Acad Sci U S A
Morita S, Groves JT.
europepmc   +1 more source

Circulating T-Cell Receptor Excision Circles at Birth and Risk of Childhood Cancers. [PDF]

Cancers (Basel)
Tao J, Albert PS, Gottlieb N, Miller P, Engels EA.   +4 more
europepmc   +1 more source

SatTCR: a pipeline for performing saturation analysis of the T cell receptor repertoire and a case study of a healthy canine. [PDF]

MethodsX
Welch Schwartz R, Zuleger CL, Newton MA, Vail DM, Albertini MR, Ong IM.   +5 more
europepmc   +1 more source

T-cell receptor anti-CMV CDR3s from bone marrow samples are associated with a worse overall survival for recurrent acute myeloid leukemia. [PDF]

Leuk Res Rep
Paul S, Aboujaoude MT, Barker VR, Hudock TR, Sahoo A, Blanck G.   +5 more
europepmc   +1 more source

A multi-branch ensemble learning framework for detection of non-small cell lung cancer via T-cell receptor sequencing. [PDF]

BMC Cancer
Wang W, Hu X, Luan Y, Chen W, Zhu Q, Tian G, Zheng Q, Meng J, Wang C, Wang M.   +9 more
europepmc   +1 more source

T cell-microbiome associations captured through T cell receptor convergence analysis

Vandoren R, Ha M, Van Deuren V, De Roeck N, Pu T, Brand EC, Kuznetsova M, Besbassi H, Bartholomeus E, Affaticati F, De Boeck I, Gehrmann T, Lebeer S, Oldenburg B, van Wijk F, Delputte P, Verbandt S, Tejpar S, Laukens K, Ogunjimi B, Meysman P.   +20 more
europepmc   +1 more source