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T-Cell Receptor Expression in the T-Cell Malignancies
American Journal of Clinical Pathology, 1990Twenty-eight cases with T-cell neoplasms (10 with T-cell acute lymphoblastic leukemia [T-ALL], 10 with T-lymphoblastic lymphoma, and 8 with peripheral T-cell lymphomas) and 2 cases with reactive lymph nodes were immunohistochemically stained with monoclonal antibodies beta F1, delta TCS1, and WT31; beta F1 antibody recognizes the beta-subunit of T-cell
N, Mori +4 more
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Designer T cells by T cell receptor replacement
European Journal of Immunology, 2006AbstractT cell receptor (TCR) gene transfer is a convenient method to produce antigen‐specific T cells for adoptive therapy. However, the expression of two TCR in T cells could impair their function or cause unwanted effects by mixed TCR heterodimers. With five different TCR and four different T cells, either mouse or human, we show that some TCR are ...
Daniel, Sommermeyer +11 more
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JAMA: The Journal of the American Medical Association, 1988
A VERTEBRATE is an attractive culture medium for viruses, bacteria, fungi, and metazoan parasites. It is therefore understandable that vertebrates have had to develop a body defense mechanism directed toward these pathogens for their emergence and survival. This defense mechanism is the See also pp 1834 and 1837. immune system.
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A VERTEBRATE is an attractive culture medium for viruses, bacteria, fungi, and metazoan parasites. It is therefore understandable that vertebrates have had to develop a body defense mechanism directed toward these pathogens for their emergence and survival. This defense mechanism is the See also pp 1834 and 1837. immune system.
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2012
T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
Jennifer D, Stone +3 more
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T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
Jennifer D, Stone +3 more
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T-Cell Receptor–Transduced T Cells
The Cancer Journal, 2015The large number of T-cell epitopes that have been found to be processed and presented on human tumors, now numbering in the hundreds, provides a rich source of targets for therapeutic interventions aimed at inducing durable tumor regression. Vaccination strategies aimed at inducing responses to these antigens have been largely ineffective, and it has ...
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2003
The antigen receptor expressed on most T-lymphocytes (T-cell antigen receptor [TCR]) is a multisubunit complex consisting of at least six different polypeptides (α, β, γ, δ, ɛ, and ζ), several of which are modified by addition of N-linked oligosaccharide chains Oligosaccharide side chains on TCR glycoproteins undergo well-characterized processing ...
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The antigen receptor expressed on most T-lymphocytes (T-cell antigen receptor [TCR]) is a multisubunit complex consisting of at least six different polypeptides (α, β, γ, δ, ɛ, and ζ), several of which are modified by addition of N-linked oligosaccharide chains Oligosaccharide side chains on TCR glycoproteins undergo well-characterized processing ...
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1981
In 1972 M. Crone, C. Koch, and M. Simonsen published a paper entitled “The elusive T cell receptor” (Crone et al. 1972), which set the stage for almost a decade of research in this area. Since then progress has been achieved only in the manner of two steps forward and one step back.
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In 1972 M. Crone, C. Koch, and M. Simonsen published a paper entitled “The elusive T cell receptor” (Crone et al. 1972), which set the stage for almost a decade of research in this area. Since then progress has been achieved only in the manner of two steps forward and one step back.
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1989
Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
P. Marrack +7 more
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Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
P. Marrack +7 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly