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T Cell Receptor CDR3 Sequences and Recombinant T Cell Receptors
International Archives of Allergy and Immunology, 2009Background: The interaction of T cell receptors (TCRs) with peptide fragments bound to major histocompatibility complex (MHC) molecules is central to the initiation and propagation of most immune responses. In order to understand and control the molecular interactions underlying T cell recognition of MHC/peptide complexes, recent efforts have focused ...
Slawomir Sowka +5 more
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2012
T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
Jennifer D, Stone +3 more
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T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
Jennifer D, Stone +3 more
openaire +2 more sources
T-Cell Receptor–Transduced T Cells
The Cancer Journal, 2015The large number of T-cell epitopes that have been found to be processed and presented on human tumors, now numbering in the hundreds, provides a rich source of targets for therapeutic interventions aimed at inducing durable tumor regression. Vaccination strategies aimed at inducing responses to these antigens have been largely ineffective, and it has ...
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2003
The antigen receptor expressed on most T-lymphocytes (T-cell antigen receptor [TCR]) is a multisubunit complex consisting of at least six different polypeptides (α, β, γ, δ, ɛ, and ζ), several of which are modified by addition of N-linked oligosaccharide chains Oligosaccharide side chains on TCR glycoproteins undergo well-characterized processing ...
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The antigen receptor expressed on most T-lymphocytes (T-cell antigen receptor [TCR]) is a multisubunit complex consisting of at least six different polypeptides (α, β, γ, δ, ɛ, and ζ), several of which are modified by addition of N-linked oligosaccharide chains Oligosaccharide side chains on TCR glycoproteins undergo well-characterized processing ...
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1981
In 1972 M. Crone, C. Koch, and M. Simonsen published a paper entitled “The elusive T cell receptor” (Crone et al. 1972), which set the stage for almost a decade of research in this area. Since then progress has been achieved only in the manner of two steps forward and one step back.
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In 1972 M. Crone, C. Koch, and M. Simonsen published a paper entitled “The elusive T cell receptor” (Crone et al. 1972), which set the stage for almost a decade of research in this area. Since then progress has been achieved only in the manner of two steps forward and one step back.
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1989
Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
P. Marrack +7 more
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Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
P. Marrack +7 more
openaire +1 more source
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly