Results 131 to 140 of about 118,951 (307)

Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets. [PDF]

J Immunother Cancer, 2023
Laletin V, Bernard PL, Costa da Silva C, Guittard G, Nunes JA.   +4 more
europepmc   +1 more source

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Freeman, Tom, Herbert, Mark, Hasegawa, Hitoshi, Willinger, Tim, Callan, Margaret F C, McMichael, Andrew J   +5 more
core  

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection [PDF]

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
Davey Martin S., Toleman Mark A., Davey, Martin S, Parish, T., Simon J. Davies, Gareth W Roberts, Williams, John David, Parish, T, Johnson, David W, John D Williams, David W Johnson, Davies, S. J., Tanya Parish, Brown, A. C., James A Chess, Chess, James Anthony, Johnson, D. W., Gareth W. Roberts, Lin Chan-Yu, Martin S. Davey, Heuston, Sinead, Toleman, Mark A., Heuston Sinéad, Cormac G. M. Gahan, Amanda C Brown, Martin S Davey, Johnson, David Westley, Roberts Gareth W., Gahan Cormac G. M., Davey, MS, Eberl, M, Gahan, C. G. M., Parish, Tanya, Chess, James A, Davies, Simon J, Hill, C., Moser Bernhard, Gahan, Cormac G M, James A. Chess, Williams, John D., Amanda C. Brown, Heuston, S., Brown, Amanda C., Moser, B, Brown, Amanda C, Davey, Martin S., Roberts, Gareth W., Johnson, David W., Toleman, MA, Toleman, Mark A, Davies Simon J., Gahan, CGM, David W. Johnson, Topley, N, Williams, John D, Bernhard Moser, Parish Tanya, Gahan, Cormac G., Topley Nicholas, Chess, JA, Moser, Bernhard, Williams, JD, Heuston, S, Johnson David W., Chess, James A., Gahan, Cormac G. M., Simon J Davies, Topley, Nicholas, Brown, AC, Hill Colin, Hill, C, Eberl, Matthias, Brown Amanda C., Davies, SJ, Mark A. Toleman, Cormac G M Gahan, Eberl Matthias, Mark A Toleman, Nicholas Topley, Hill, Colin, Chan-Yu Lin, Colin Hill, Toleman, Mark Alexander Howard, Roberts, GW, Lin, CY, Johnson, DW, Chess James A., Lin, Chan-Yu, Williams John D., Davies, Simon J., John D. Williams, Sinéad Heuston, Roberts, Gareth W, Matthias Eberl   +93 more
core   +2 more sources

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines.
Rajesh Lamichhane, Marion Schneider, Sara M. de la Harpe, Thomas W.R. Harrop, Rachel F. Hannaway, Peter K. Dearden, Joanna R. Kirman, Joel D.A. Tyndall, Andrea J. Vernall, James E. Ussher   +9 more
doaj   +1 more source

Use of monoclonal antibodies to study alloreactivity and T cell development in Xenopus [PDF]

, 1993
This study investigated T-cell surface antigenic changes in the spleen of Xenopus following in vivo and in vitro allergenic challenge, using novel mouse monoclonal antibodies (mAb's) against all T cells (CDS), the putative ɑβ-T cell receptor (TCR), the ...
Paul, Tina
core  

Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden [PDF]

, 2011
BACKGROUND:The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden.
Ngom, Pa T, Solon Juan, Ngom Pa T, Andrew M Prentice, Morgan Gareth, Juan Solon, Prentice Andrew M, Richard Aspinall, Morgan, Gareth, Pa T Ngom, Prentice, Andrew M, Sophie E Moore, Aspinall, Richard, Gareth Morgan, Moore, Sophie E, Solon, Juan, Ngom, Pa T., Moore, Sophie E., Prentice, Andrew M., Aspinall Richard, Moore Sophie E   +20 more
core   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

T cell receptor-directed antibody-drug conjugates for the treatment of T cell-derived cancers

Molecular Therapy: Oncology
T cell-derived cancers are hallmarked by heterogeneity, aggressiveness, and poor clinical outcomes. Available targeted therapies are severely limited due to a lack of target antigens that allow discrimination of malignant from healthy T cells.
Katrin Schoenfeld, Jan Habermann, Philipp Wendel, Julia Harwardt, Evelyn Ullrich, Harald Kolmar   +5 more
doaj   +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source