Results 141 to 150 of about 118,951 (307)
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis). [PDF]
BMC Genomics, 2022 Jaiswal S +14 more
europepmc +1 more source
Generation and phenotypic analysis of coronin-1 deficient mice [PDF]
, 2006 Coronins represent an evolutionary conserved family of WD-repeat actin-binding proteins for which a role in regulating membrane and cytoskeleton related functions have been proposed. In mammalian organisms seven members of the coronin protein family have
Massner, Jan Christian Louis
core +1 more source
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis &Rheumatology, EarlyView.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source
Anti-tumor memory CD4 and CD8 T-cells quantified by bulk T-cell receptor (TCR) clonal analysis. [PDF]
Front Immunol, 2023 Gao Y, Bergman I.
europepmc +1 more source
Arthritis &Rheumatology, Accepted Article.Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway +13 more
wiley +1 more source
MedCommT‐cell receptor (TCR) engineered T‐cell therapy, unlike chimeric antigen receptor T‐cell therapy, relies on the inherent ability of TCRs to detect a wider variety of antigenic epitopes, such as protein fragments found internally or externally on cells ...
Qin Wang +10 more
doaj +1 more source
Constraints on the CD8 T cell response in chronic HBV infection [PDF]
, 2009 The inflamed liver in chronic hepatitis B virus infection (CHB) is characterised by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting.
Das, A., Das, A
core
Arthritis &Rheumatology, EarlyView.Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source
Evolution of CD8+ T Cell Receptor (TCR) Engineered Therapies for the Treatment of Cancer. [PDF]
Cells, 2021 Sun Y +6 more
europepmc +1 more source