Results 271 to 280 of about 118,951 (307)

T Cell Receptor (TCR) Repertoire in Alloimmune Responses

International Reviews of Immunology, 1996
A large number of alloantigenic determinants could be generated by both the direct and indirect alloantigen presentation pathways. Hence, a heterogeneous population of T cells expressing a wide variety of receptors would be expected to respond to this diverse array of alloantigenic determinants.
Olivera J Finn, Lisa A Debruyne, D Keith Bishop   +2 more
exaly   +3 more sources

The role of lipid rafts in T cell antigen receptor (TCR) signalling

Seminars in Immunology, 2000
Plasma membranes of many cell types contain domains enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell antigen receptor (TCR) signalling molecules associate with rafts, and disrupting raft-association of certain of these abrogates TCR signalling.
Peter W Janes, Steven C Ley, Anthony I Magee   +2 more
exaly   +3 more sources

T-cell receptor structure and TCR complexes

Current Opinion in Structural Biology, 1997
The first crystal structures of intact T-cell receptors (TCRs) and their complexes with MHC peptide antigens (pMHC) were reported during the past year, along with those of a single-chain TCR Fv fragment and a beta-chain complexed with two different bacterial superantigens. These structures have shown the similarities and differences in the architecture
I A, Wilson, K C, Garcia
openaire   +2 more sources

The T Cell Receptor (TCR) in HLA-B27-Restricted T Cell Responses - an Introduction

Clinical Rheumatology, 1996
Recent data indicate that cytotoxic T lymphocytes (CTL) are involved in the pathogenesis of HLA-B27-associated spondylarthropathies. In the absence of clearly defined "arthritogenic" bacterial or self peptides that are presented by HLA-B27 and recognized by such CD8+CTL, one approach has been to investigate the T cell repertoire of lesional cellular ...
E, Märker-Hermann, R, Duchmann, E, May, B, Ackermann, K H, Meyer Zum Büschenfelde   +4 more
openaire   +2 more sources

Studies on the T Cell Receptor (TCR) Revision of Autoantibody-Inducing CD4 T (aiCD4 T) Cell

2014
Our recent studies into the role of autoantibody-inducing CD4 T cells in autoimmune disease have necessitated studies on the mechanism of TCR revision, a phenomenon that has been difficult to approach experimentally. Here we describe a detailed experimental technique to investigate the molecular events involved in TCR revision.
Shunichi, Shiozawa, Kenichi, Uto
openaire   +2 more sources

Characterization of T cell receptor (TCR) of organ-specific autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines

Journal of Neuroimmunology, 2000
Organ-specific autoimmune diseases and their animal models are characterized by the finding that the development of the diseases is closely associated with, or induced by, T cells reactive to organ-specific antigens. Therefore, the identification of T cell receptors (TCR) used by disease-inducing T cells within a short period of time is a key factor ...
openaire   +2 more sources