Results 151 to 160 of about 3,681,633 (268)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efficient gene disruption with CRISPR-Cas3 in human T cells. [PDF]

NAR Cancer
Fujii T, Sakoda Y, Yoshimi K, Takeshita K, Watanabe S, Iida R, Obo T, Yokoyama K, Tamada K, Mashimo T.   +9 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

IL-6 is one of the key factors in the formation of gut tissue resident memory T cells from Naïve T cells. [PDF]

PLoS Pathog
Kim HG, Chan A, Vimopatranon S, Girard A, Jiang A, Wertz S, Hwang IY, Kehrl JH, Schmeisser H, Seemiller MM, Lusso P, Huang D, Wei D, Goes LR, Soares M, Martinelli E, Arthos J, Cicala C.   +17 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

CAR-T Cells: Current Status, Challenges, and Future Prospects. [PDF]

MedComm (2020)
Adly AS, Cartron G, Adly AS, Egea JC, Dutilleul PC, Adly MS, Villalba M.   +6 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Depletion of NAT10 in T cells attenuates metabolic dysfunction-associated steatohepatitis in mice. [PDF]

Hepatol Commun
Yang Y, Lu J, Ma M, Zhou J, Wang E, Lu Y, Dai Z, Zhou B, Li Y.   +8 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The neurotoxic legacy of CAR-T cells: where do we stand? [PDF]

Ther Adv Neurol Disord
Pagliuca S, Jacquet C, Rubio MT, Sorrentino P.   +3 more
europepmc   +1 more source