Results 151 to 160 of about 41,042,307 (363)

Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APCmin/+ mice [PDF]

, 2018
Tumor-infiltrating lymphocytes are crucial for anti-tumor immunity. We have previously shown that regulatory T cells (Treg) are able to reduce T-cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo ...
Szeponik, Louis,, Marianne Quiding-Järbrink, Alsén, Samuel, Sundström, Patrik,, Sundström, Patrik, Gustavsson, Bengt,, Raghavan, Sukanya, Sparwasser, Tim, Quiding-Järbrink, Marianne,, Louis Szeponik, Sukanya Raghavan, Akeus, Paulina, Tim Sparwasser, Quiding-Järbrink, Marianne, Szeponik, Louis, Raghavan, Sukanya,, Gustavsson, Bengt, Patrik Sundström, Ahlmanner, Filip,, Filip Ahlmanner, Alsén, Samuel,, Samuel Alsén, Sparwasser, T., Bengt Gustavsson, Akeus, Paulina,, Paulina Akeus, Ahlmanner, Filip   +26 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Lei, Y., Jeker, L. T., Georg A. Holländer, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Nagasawa, T., Izumi Ohigashi, Ripen, A. M., Ohigashi, I., Takashi Nagasawa, Malefyt Rde, W., Adiratna Mat Ripen, Nitta, Takeshi, Ripen, Adiratna Mat, Bösl, Michael R., Lei, Yu, de Waal Malefyt, Rene, Jeker, Lukas T., Ishimaru, Naozumi, Hayashi, Yoshio, Takahama, Yousuke, Ohigashi, Izumi, Nagasawa, Takashi, Holländer, Georg A.   +35 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells

OncoImmunology, 2019
Most chronic viruses evade T-cell and natural killer (NK) immunity through downregulation of immune surface markers. Previously we showed that Pomalidomide (Pom) increases surface expression of major histocompatibility complex class I (MHC-I) in Kaposi ...
David A. Davis, Prabha Shrestha, Ashley I. Aisabor, Alexandra Stream, Veronica Galli, Cynthia A. Pise-Masison, Takanobu Tagawa, Joseph M. Ziegelbauer, Genoveffa Franchini, Robert Yarchoan   +9 more
doaj   +1 more source

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

New England Journal of Medicine, 2017
Background Patients with diffuse large B‐cell lymphoma or follicular lymphoma that is refractory to or that relapses after immunochemotherapy and transplantation have a poor prognosis.
S. Schuster, J. Svoboda, E. Chong, S. Nasta, A. Mato, Ö. Anak, J. Brogdon, Iulian Pruteanu-Malinici, Vijay G. Bhoj, D. Landsburg, M. Wasik, B. Levine, S. Lacey, J. Melenhorst, D. Porter, C. June   +15 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

OncoImmunology, 2017
Background – The presence of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment is associated with an improved prognosis and a better response to therapy in different types of cancer.
Emma J. de Ruiter, Marc L. Ooft, Lot A. Devriese, Stefan M. Willems   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source