Results 181 to 190 of about 27,916,234 (409)

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. [PDF]

, 1993
Cognate interactions between antigen-presenting B and T cells play crucial roles in immunologic responses. T cells that have been activated via the crosslinking of CD3 are able to induce B cell proliferation and immunoglobulin secretion in a major ...
Kipps, TJ, Ranheim, EA
core  

Proliferation-driven mechanical feedback regulates cell dynamics in growing tissues [PDF]

arXiv
Local stresses in a tissue, a collective property, regulate cell division and apoptosis. In turn, cell growth and division induce active stresses in the tissue. As a consequence, there is a feedback between cell growth and local stresses. However, how the cell dynamics depend on local stress-dependent cell division and the feedback strength is not ...
arxiv  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Nature Communications, 2018
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103+CD39+ tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both ...
T. Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, T. Moudgil, N. D. de Miranda, C. Goodall, T. Blair, B. Fox, J. Mcdermott, Shu-ching Chang, G. Grunkemeier, R. Leidner, R. Bell, A. Weinberg   +14 more
semanticscholar   +1 more source

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Blount, Daniel G, Couper, Kevin N, de Souza, J Brian, Greig, Rachel, Gwyer Findlay, Emily, Hafalla, Julius CR, Hunter, Christopher A, Riley, Eleanor M, Shaw, Tovah N, Stumhofer, Jason S, Villegas-Mendez, Ana   +10 more
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Improving efficacy of cancer immunotherapy through targeting of macrophages

Human Vaccines & Immunotherapeutics, 2019
T cell-based immunotherapies have revolutionized the treatment against cancer. But complete and long-lasting efficacy is only observed in a fraction of the patient population.
Elisa Peranzoni, Emmanuel Donnadieu
doaj   +1 more source

VIRUS-SPECIFIC NUCLEIC ACIDS IN SV40-EXPOSED HAMSTER EMBRYO CELL LINES: CORRELATION WITH S AND T ANTIGENS [PDF]

, 1969
Myron J. Levin, Michael N. Oxman, George Th. Diamandopoulos, Arthur S. Levine, Patrick H. Henry, John F. Enders   +5 more
openalex   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Cells in Multidimensional Recurrent Neural Networks [PDF]

Journal of Machine Learning Research 17 (2016) 1-37, 2014
The transcription of handwritten text on images is one task in machine learning and one solution to solve it is using multi-dimensional recurrent neural networks (MDRNN) with connectionist temporal classification (CTC). The RNNs can contain special units, the long short-term memory (LSTM) cells.
arxiv