Results 51 to 60 of about 7,436,963 (336)
The Pan African Medical Journal, 2018 Macrophage activation syndrome (MAS) is a severe and potentially fatal life-threatening condition associated with excessive activation and expansion of T cells with macrophages and a high expression of cytokines, resulting in an uncontrolled inflammatory
Zakia Sefsafi +4 more
doaj +1 more source
Cell–cell and cell–matrix interactions
Molecular Biology of the Cell, 2014 mbc.E13-11-0671 Molecular Biology of the Cell Volume 25 Page 731 MBoC is pleased to publish this summary of the Minisymposium “Cell−Cell/Cell−Matrix Interactions and Intracellular Signaling” held at the American Society for Cell Biology 2013 Annual Meeting, New Orleans, LA, December 15, 2013.
openaire +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Role of Dendritic Cells in Exposing Latent HIV-1 for the Kill
Viruses, 2019 The development of effective yet nontoxic strategies to target the latent human immunodeficiency virus-1 (HIV-1) reservoir in antiretroviral therapy (ART)-suppressed individuals poses a critical barrier to a functional cure.
Jan Kristoff +2 more
doaj +1 more source
Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells. [PDF]
, 1989 We report here a mAb, 14-2, reactive with TCRs that include V beta 14. The frequency of V beta 14+ T cells varies with CD4 and CD8 subset and is controlled by the H-2 genes.
Liao, N, Maltzman, J, RAULET, David H.
core
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Impact of curative radiotherapy on the immune status of patients with localized prostate cancer
OncoImmunology, 2018 Combination of radiotherapy with immunotherapy has become an attractive concept for the treatment of cancer. The objective of this study was to assess the effect of curative, normofractionated radiotherapy on peripheral immune lymphocytes in prostate ...
Franziska Eckert +6 more
doaj +1 more source
Vinculin in cell–cell and cell–matrix adhesions [PDF]
Cellular and Molecular Life Sciences, 2017 Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions.
Jennifer L. Bays, Kris A. DeMali
openaire +2 more sources
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source