Results 51 to 60 of about 7,102,622 (207)

Distinct profiles of osteoclast and dendritic cell-mediated expansion and functional activation of NK and T cells

Cancer Immunology, Immunotherapy
Osteoclasts (OCs) and dendritic cells (DCs) induce expansion and functional activation of NK and T cells. When comparing OCs with DC-induced activation in NK cells, OCs induced significantly higher cell expansion and functional activation of NK cells as ...
Kawaljit Kaur, Anahid Jewett
doaj   +1 more source

The Impact of Obesity on T and NK Cells after LVAD Implantation

Obesity Facts, 2023
Introduction: Infections are a major problem after left ventricular assist device (LVAD) implantation that affects morbidity, mortality, and the quality of life. Obesity often increases the risk for infection.
Eva Katharina Messer, Anna Lassia Meyer, Kristin Klaeske, Franz Sieg, Sandra Eifert, Dominik Schmiedel, Josephina Haunschild, Khalil Jawad, Diyar Saeed, Lea Hildebrandt, Michael Andrew Borger, Maja-Theresa Dieterlen   +11 more
doaj   +1 more source

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer. [PDF]

, 2019
Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy.
Bruni E, Cazzetta V, Cimino M, Dieli F, Donadon M, Leonardi G, Mavilio D., Mikulak J, Spata G, Torzilli G   +9 more
core   +1 more source

T-cell activation

Trends in Cell Biology, 1992
Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca(2+) levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells.
Izquierdo, Manuel, Cantrell, Doreen A.
openaire   +4 more sources

TEIPP peptides: exploration of unTAPped cancer antigens

OncoImmunology, 2019
The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers.
Koen A. Marijt, Sjoerd H. Van Der Burg, Thorbald van Hall   +2 more
doaj   +1 more source

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. [PDF]

, 2012
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation.
Banigan, Edward J, Christian, David A, Harris, Tajie H, Hunter, Christopher A, John, Beena, Konradt, Christoph, Liu, Andrea J, Luster, Andrew D, Norose, Kazumi, Tait Wojno, Elia D, Weninger, Wolfgang, Wilson, Emma H   +11 more
core   +2 more sources

SUPERANTIGENS

Acta Agriculturae Slovenica, 1998
Superantigens are bacterial, viral, retroviral and some naturally occurring proteins that can specifically activate a large proportion of T and/or B cells.
Mojca NARAT
doaj   +1 more source

Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T Cells [PDF]

, 2016
Background/Aims: Activation of T cell receptors (TCRs) in CD4+ T cells leads to a cascade of signalling reactions including increase of intracellular calcium (Ca2+) levels with subsequent Ca2+ dependent stimulation of gene expression, proliferation, cell
Abousaab, A, Al-Maghout, T, Bissinger, R, Cheng, A, Cobb, B S, Lang, F, Pelzl, L, Salker, M S, Singh, Y, Zhang, S, Zhou, Y   +10 more
core   +3 more sources

Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer

OncoImmunology, 2018
Advanced bladder cancer patients have limited therapeutic options resulting in a median overall survival (OS) between 12 and 15 months. Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) has been used successfully in treating patients
Michael Poch, MacLean Hall, Autumn Joerger, Krithika Kodumudi, Matthew Beatty, Pasquale P. Innamarato, Brittany L. Bunch, Mayer N. Fishman, Jingsong Zhang, Wade J. Sexton, Julio M. Pow-Sang, Scott M. Gilbert, Philippe E. Spiess, Jasreman Dhillon, Linda Kelley, John Mullinax, Amod A Sarnaik, Shari Pilon-Thomas   +17 more
doaj   +1 more source

Anti-tumor immunity influences cancer cell reliance upon ATG7

OncoImmunology, 2020
Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it has been shown to inhibit, promote
Michael D. Arensman, Xiaoran S. Yang, Wenyan Zhong, Stephanie Bisulco, Erik Upeslacis, Edward C. Rosfjord, Shibing Deng, Robert T. Abraham, Christina H. Eng   +8 more
doaj   +1 more source