Results 61 to 70 of about 7,211,460 (310)

Selective inhibition of T suppressor-cell function by a monosaccharide [PDF]

, 1981
Interactions between regulatory T lymphocytes and other cells are assumed to occur at the level of the cell surface. T cells which suppress the generation of specifically effector cells have been described as having antigenic, idiotypic, allotypic and I ...
AA Moscona, B Benacerraf, CG Orosz, DH Boldt, DL Peavy, FM Rollwagen, H Lis, IFC McKenzie, J Moss, JE Geltosky, K Eichmann, LA Herzenberg, LB Grabel, LM Nadler, Michael Kramer, RE Rocklin, RM Ferguson, RW Dutton, SH Barondes, T Tada, U Koszinowski, Ulrich H. Koszinowski, VT Marchesi   +22 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Function and mechanisms of T cells in the damage and repair of lung epithelial cells

生物医学转化, 2023
Lung epithelial cells play a protective role in the respiratory system. However, various pathological factors such as infection, trauma, and inflammation can lead to damage to lung epithelial cells, causing lung diseases.
Liu Enzhuo, Liu Zhichun, Wen Zhenke
doaj   +1 more source

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]

PLOS Computational Biology. 2015 Apr 2;11(4):e1004179, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spreading mechanism, which is also a characteristic of some important computer worm outbreaks, to HIV-1 ...
arxiv   +1 more source

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells [PDF]

, 2018
The persistence of HIV reservoirs, including latently infected, resting CD4+ T cells, is the major obstacle to cure HIV infection. CD32a expression was recently reported to mark CD4+ T cells harboring a replication-competent HIV reservoir during ...
Abdel-Mohsen, Mohamed, Betts, Michael R., Buzon, Maria J., Castellvi, Josep, Cox, Kara, Del Rio Estrada, Perla M., Frank, Ian, Genesca, Meritxell, Giron, Leila B., Gonzalez-Navarro, Mauricio, Grau-Exposito, Judith, Hazuda, Daria, Howell, Bonnie, King, Collin T., Kostman, Jay, Kuri-Cervantes, Leticia, Li, Qingsheng, Lynn, Kenneth, Martinez-Picado, Javier, Montaner, Luis J., Mounzer, Karam, Nell, Racheal A., Paiardini, Mirko, Planelles, Vicente, Reyes-Teran, Gustavo, Richman, Douglas, Serra-Peinado, Carla, Spivak, Adam M., Tebas, Pablo, Tomescu, Costin, Vadrevu, Surya Kumari, Vemula, Sai, Wan, Yanmin, Wu, Guoxin   +33 more
core   +1 more source

Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice [PDF]

, 2012
Pneumoviruses such as pneumonia virus of mice (PVM), bovine respiratory syncytial virus (bRSV) or human (h)RSV are closely related pneumoviruses that cause severe respiratory disease in their respective hosts.
Alice J.A.M. Sijts, Alwan, Andrea Gröne, Andrew J. Easton, Bossert, Braciale, Buchholz, Cannon, Castilow, Chang, Chen, Chin, Claassen, Claassen, Claire J.P. Boog, Cornelis P.J. Bekker, David J. Topham, Dietmar M.W. Zaiss, Dirk H. Busch, Easton, Falsey, Fenton, Frey, Fulginiti, Garvey, Graham, Hall, Heinze, Henderson, Hussell, Kapikian, Kim, Kruijsen, Kulkarni, Lo, Mary J.G. van Helden, Ostler, Ostler, Percopo, Peter J.S. van Kooten, Piedra, Polakos, Rosenberg, Rosenberg, Sherman, Srikiatkhachorn, Stevens, Stevens, Thompson, Tregoning, Varga, Zaiss   +51 more
core   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu, A Kadioglu, A Nalbant, A Strasser, AD Badley, Andrea M. Mitchell, C Riccardi, CA Janeway Jr, CK Sung, D Zhou, David H. Dockrell, DH Dockrell, DH Dockrell, DH Dockrell, DR Cundell, EE McGrath, FK Swirski, Frank R. DeLeo, G Matute-Bello, Helen M. Marriott, HM Marriott, HM Marriott, I Nicoletti, J Warwick-Davies, JA Carrero, Julie A. Preston, K Beiter, K Kemp, K LeMessurier, KA Browne, KE Price, L Galluzzi, L Maggi, L Ziegler-Heitbrock, LA Kirkham, M Daigneault, M Lenardo, M Witzenrath, MA Barocchi, MA Bewley, Marc Daigneault, Martin A. Bewley, MJ Jedrzejas, Moira K. B. Whyte, N Olivares-Zavaleta, N Oyaizu, NV Serbina, PA Kiener, R Malley, RA Hirst, Robert C. Read, RS Hotchkiss, RS Hotchkiss, RS Hotchkiss, SE Weber, SJ Webster, SL Newman, T Mattern, T Takahashi, Thushan I. De Silva, Timothy J. Mitchell, WL Farrar, WP Hausdorff, YJ Lu, Z Zhang   +64 more
core   +3 more sources

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity

OncoImmunology, 2019
Eradication of tumors by the immune system relies on the efficient activation of a T-cell response. For many years, the main focus of cancer immunotherapy has been on cytotoxic CD8 T-cell.
Nadia Mensali, Amalie Grenov, Niladri Bhusan Pati, Pierre Dillard, Marit Renée Myhre, Gustav Gaudernack, Gunnar Kvalheim, Else Marit Inderberg, Oddmund Bakke, Sébastien Wälchli   +9 more
doaj   +1 more source