Results 61 to 70 of about 27,710,413 (387)
CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]
, 2012 Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin +2 more
core +5 more sources
Clonal replacement of tumor-specific T cells following PD-1 blockade
Nature Medicine, 2019 Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the clinical care of patients with cancer1. However, whether the T cell response to checkpoint blockade relies on reinvigoration of pre-existing tumor-infiltrating ...
K. Yost +15 more
semanticscholar +1 more source
Senolytic CAR T cells reverse senescence-associated pathologies
Nature, 2020 Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment1,2. Physiologically, senescence serves as a tumour-suppressive mechanism that prevents the expansion of premalignant ...
Corina Amor +17 more
semanticscholar +1 more source
Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus +6 more
wiley +1 more source
OncoImmunology, 2018 Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes.
Marit M. Melssen +10 more
doaj +1 more source
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta [PDF]
, 2007 The induction of regulatory T (T reg) cells holds considerable potential as a treatment for autoimmune diseases. We have previously shown that CD4(+)CD25(hi) T reg cells isolated from patients with active rheumatoid arthritis (RA) have a defect in their ...
Ehrenstein, MR, Mauri, C, Nadkarni, S
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine +10 more
wiley +1 more source
Journal of Immunotoxicology, 2021 Multiple sclerosis (MS) causes neurologic disabilities that effect musculature, sensory systems, and vision. This is largely due to demyelination of nerve fibers caused by chronic inflammation.
Kok-Tong Tan +4 more
doaj +1 more source
Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]
, 2019 Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi +3 more
core +2 more sources
Trends in Cell Biology, 1992 Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca(2+) levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells.
Izquierdo, Manuel, Cantrell, Doreen A.
openaire +4 more sources