Results 81 to 90 of about 27,710,413 (387)

TEIPP peptides: exploration of unTAPped cancer antigens

OncoImmunology, 2019
The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers.
Koen A. Marijt, Sjoerd H. Van Der Burg, Thorbald van Hall   +2 more
doaj   +1 more source

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C, Freeman, Tom, Hasegawa, Hitoshi, Herbert, Mark, McMichael, Andrew J, Willinger, Tim   +5 more
core   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis [PDF]

, 2023
Isaac Narbona-Sánchez, Alba Pérez-Linaza, Isabel Serrano-García, Inmaculada Vico-Barranco, Luis M. Fernández-Aguilar, José L. Poveda-Díaz, Marı́a Jesús Sánchez-del-Pino, Fermín Medina‐Varo, Mikel M. Arbulo-Echevarria, Enrique Aguado   +9 more
openalex   +1 more source

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. [PDF]

, 2012
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation.
Banigan, Edward J, Christian, David A, Harris, Tajie H, Hunter, Christopher A, John, Beena, Konradt, Christoph, Liu, Andrea J, Luster, Andrew D, Norose, Kazumi, Tait Wojno, Elia D, Weninger, Wolfgang, Wilson, Emma H   +11 more
core   +2 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer

OncoImmunology, 2018
Advanced bladder cancer patients have limited therapeutic options resulting in a median overall survival (OS) between 12 and 15 months. Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) has been used successfully in treating patients
Michael Poch, MacLean Hall, Autumn Joerger, Krithika Kodumudi, Matthew Beatty, Pasquale P. Innamarato, Brittany L. Bunch, Mayer N. Fishman, Jingsong Zhang, Wade J. Sexton, Julio M. Pow-Sang, Scott M. Gilbert, Philippe E. Spiess, Jasreman Dhillon, Linda Kelley, John Mullinax, Amod A Sarnaik, Shari Pilon-Thomas   +17 more
doaj   +1 more source

SUPERANTIGENS

Acta Agriculturae Slovenica, 1998
Superantigens are bacterial, viral, retroviral and some naturally occurring proteins that can specifically activate a large proportion of T and/or B cells.
Mojca NARAT
doaj   +1 more source

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE).
Chai, Zhi, Ciric, Bogoljub, Curtis, Mark T., Guo, Min-Fang, Li, Rui-Lan, Li, Yan-Hua, Ma, Cun-Gen, Rostami, A. M., Song, Guo-Bin, Sun, Man-Luan, Thome, Rodolfo, Xu, Fang, Zhang, Guang-Xian   +12 more
core   +1 more source

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection [PDF]

, 2015
ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition-dependent tumor metastasis.
Agata Stryjewska, Alexander Weidemann, Ananda W. Goldrath, Best, Bingfei Yu, Brabletz, Cannarile, Christiane Zweier, Conidi, Danny Huylebroeck, Engel, Eve Seuntjens, Garavelli, Gattinoni, Goldrath, Goossens, Goossens, Grégoire, Gründemann, Hand, Haring, Harney, Harney, Harty, Higashi, Higashi, Hikono, Hikono, Hisato Kondoh, J. Adam Best, Jessica V. Nguyen, Jody Haigh, Joshi, Kaech, Kaech, Kaech, Kaech, Kallies, Knell, Kyla D. Omilusik, Larabee, Lin, Luca Gattinoni, Lynne M. Bird, Massari, Masson, Mowat, Murre, Olson, Postigo, Postigo, Rahul Roychoudhuri, Remacle, Rice, Rubinstein, Sarkar, Sawada, Sekido, Seuntjens, Steven Goossens, Takemoto, Van de Putte, van den Berghe, van Grunsven, Verschueren, Verstappen, Voehringer, Williams, Wirth, Yang, Yasui, Yujiro Higashi, Zweier   +72 more
core   +3 more sources