Results 81 to 90 of about 7,102,622 (207)

Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer

open access: yesOncoImmunology, 2018
Strategies to enhance tumor immunogenicity may expand the role of immunotherapy beyond the mismatch repair-deficient subtype. In this pilot study, biopsies were performed at baseline and after four cycles of FOLFOX in eight patients receiving neoadjuvant
Campbell S. Roxburgh   +4 more
doaj   +1 more source

ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.

open access: yes, 2001
The enzyme-linked immunospot technique (ELISPOT) relies on the visualization of cytokine secretion by individual T cells following in vitro stimulation with antigen. This assay has been developed and standardized for the quantitative detection of antigen-
Carvalho, LH, Hafalla, JC, Zavala, F
core   +1 more source

Frequent adaptive immune responses against arginase-1

open access: yesOncoImmunology, 2018
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite   +9 more
doaj   +1 more source

A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. [PDF]

open access: yes, 1992
We have previously reported that T cells bearing T cell receptors (TCRs) of gamma/delta type appear at a relatively early stage of primary infection with Listeria monocytogenes in mice.
Bluestone, JA   +7 more
core  

CEACAM1 as a multi-purpose target for cancer immunotherapy

open access: yesOncoImmunology, 2017
CEACAM1 is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system.
Matthew Dankner   +4 more
doaj   +1 more source

Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. [PDF]

open access: yes, 2019
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood.
Cyster, Jason G   +4 more
core   +1 more source

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

open access: yes, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud   +11 more
core   +1 more source

Chronic Atrophic Autoimmune Gastritis: The Evolving Role of Vitamin D

open access: yesFrontiers in Bioscience-Landmark
Vitamin D possesses a crucial role in preserving bone health, modulating the immune system responses, and supporting various physiological functions throughout the body.
Ioanna Aggeletopoulou   +2 more
doaj   +1 more source

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