Results 81 to 90 of about 7,436,963 (336)

The interplay of cell–cell and cell–substrate adhesion in collective cell migration [PDF]

Journal of The Royal Society Interface, 2014
Collective cell migration often involves notable cell–cell and cell–substrate adhesions and highly coordinated motion of touching cells. We focus on the interplay between cell–substrate adhesion and cell–cell adhesion. We show that the loss of cell-surface contact does not significantly alter the dynamic pattern of protrusions and ...
Chenlu, Wang, Sagar, Chowdhury, Meghan, Driscoll, Carole A, Parent, S K, Gupta, Wolfgang, Losert   +5 more
openaire   +2 more sources

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia [PDF]

, 2004
We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell production through the thymus or from poor
Bingham, S.J., Brown, A.K., Buch, M., Douglas, S.H., Emery, P., Fearon, U., Field, S.L., Isaacs, J.D., Lawson, C.A., Ma, D., Maltby, S.L., Markham, A.F., Masurel, A., McGonagle, D., Moore, J., Morgan, A.W., Papadaki, H.A., Patel, P., Ponchel, F., Protheroe, A., Quinn, M., Short, K., Snowden, J., Straszynski, L., van Laar, J.M., Veale, D.J., Verburg, R.J.   +26 more
core   +2 more sources

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant

OncoImmunology, 2017
Among reported advantages of umbilical cord blood (CB) in transplantation is lower leukemia relapse probability. Underlying cellular mechanisms of graft-vs.-leukemia (GVL) are thought to include a prominent role for T cells.
Sami B. Kanaan, Hilary S. Gammill, Whitney E. Harrington, Stephen C. De Rosa, Philip A. Stevenson, Alexandra M. Forsyth, Judy Allen, Emma Cousin, Koen van Besien, Colleen S. Delaney, J. Lee Nelson   +10 more
doaj   +1 more source

Cell Simulation as Cell Segmentation

Nature Methods
AbstractSingle-cell spatial transcriptomics promises a highly detailed view of a cell’s transcriptional state and microenvironment, yet inaccurate cell segmentation can render this data murky by misattributing large numbers of transcripts to nearby cells or conjuring nonexistent cells.
Daniel C. Jones, Anna E. Elz, Azadeh Hadadianpour, Heeju Ryu, David R. Glass, Evan W. Newell   +5 more
openaire   +3 more sources

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

The Network of miRNA–mRNA Interactions in Circulating T Cells of Patients Following Major Trauma – A Pilot Study

Journal of Inflammation Research, 2022
Cheng-Shyuan Rau1 *, Pao-Jen Kuo2 *, Hui-Ping Lin,2 Chia-Jung Wu,2 Yi-Chan Wu,2 Peng-Chen Chien,2 Ting-Min Hsieh,3 Hang-Tsung Liu,3 Chun-Ying Huang,3 Ching-Hua Hsieh2 1Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang ...
Rau CS, Kuo PJ, Lin HP, Wu CJ, Wu YC, Chien PC, Hsieh TM, Liu HT, Huang CY, Hsieh CH   +9 more
doaj  

A fit of CD4⁺ T cell immune response to an infection by lymphocytic choriomeningitis virus

Mathematical Biosciences and Engineering, 2019
We fit an immune response model to data reporting the CD4+ T cell numbers from the 28 days following the infection of mice with lymphocytic choriomeningitis virus LCMV. We used an ODE model that was previously used to describe qualitatively the behaviour
Atefeh Afsar , Filipe Martins, Bruno M. P. M. Oliveira , Alberto A. Pinto   +3 more
doaj   +1 more source

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients experience treatment resistance.
Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W. Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P.E. Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esther C.W. Breij, Maria Jure-Kunkel, Ugur Sahin   +20 more
doaj   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source