Results 81 to 90 of about 7,102,622 (207)
Strategies to enhance tumor immunogenicity may expand the role of immunotherapy beyond the mismatch repair-deficient subtype. In this pilot study, biopsies were performed at baseline and after four cycles of FOLFOX in eight patients receiving neoadjuvant
Campbell S. Roxburgh +4 more
doaj +1 more source
ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.
The enzyme-linked immunospot technique (ELISPOT) relies on the visualization of cytokine secretion by individual T cells following in vitro stimulation with antigen. This assay has been developed and standardized for the quantitative detection of antigen-
Carvalho, LH, Hafalla, JC, Zavala, F
core +1 more source
Frequent adaptive immune responses against arginase-1
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite +9 more
doaj +1 more source
A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. [PDF]
We have previously reported that T cells bearing T cell receptors (TCRs) of gamma/delta type appear at a relatively early stage of primary infection with Listeria monocytogenes in mice.
Bluestone, JA +7 more
core
CEACAM1 as a multi-purpose target for cancer immunotherapy
CEACAM1 is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system.
Matthew Dankner +4 more
doaj +1 more source
Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. [PDF]
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood.
Cyster, Jason G +4 more
core +1 more source
An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud +11 more
core +1 more source
Chronic Atrophic Autoimmune Gastritis: The Evolving Role of Vitamin D
Vitamin D possesses a crucial role in preserving bone health, modulating the immune system responses, and supporting various physiological functions throughout the body.
Ioanna Aggeletopoulou +2 more
doaj +1 more source

