Results 81 to 90 of about 7,211,460 (310)

A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD8+ T cell immune response [PDF]

arXiv, 2021
Intra-tumour heterogeneity (ITH) has a strong impact on the efficacy of the immune response against solid tumours. The number of sub-populations of cancer cells expressing different antigens and the percentage of immunogenic cells (i.e. tumour cells that are effectively targeted by immune cells) in a tumour are both expressions of ITH. Here, we present
arxiv  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Confirmation that T cell receptor activation is digital, not analog. Hence individual T cell cytolytic capacity is independent of initial stimulation strength [PDF]

arXiv, 2018
Whether a sub-optimum lymphocyte stimulus is achieved by lowering ligand concentration, or decreasing its affinity, initial TCR activation responses are likely to be digital. We now know for cultured peripheral blood mononuclear cells (PBMCs), when activated by plant lectins such as concanavalin-A (Con-A), that the responding cells are T cells, and ...
arxiv  

Mechanism of T-Cell Lymphomagenesis: Transformation of Growth-Factor-Dependent T-Lymphoblastoma Cells to Growth-Factor-Independent T-Lymphoma Cells [PDF]

, 1984
In a previous paper we described the induction by x-irradiation or radiation-induced leukemia virus-in-oculation of two classes of lymphoid T-cell neoplasms: The first class, designated T-cell lymphoblastoma (TCLB), consists of growth-factor-dependent ...
Altman, Amnon, Bogart, Mark H., Haas, Martin, Jones, O. W., Rothenberg, Ellen   +4 more
core   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype

OncoImmunology, 2018
Pancreatic Ductal Adenocarcinoma (PDA) is characterized by a complex tumor microenvironment that supports its progression, aggressiveness and resistance to therapies.
Simone Borgoni, Andrea Iannello, Santina Cutrupi, Paola Allavena, Maurizio D'Incalci, Francesco Novelli, Paola Cappello   +6 more
doaj   +1 more source

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
A Franco, AB Lyons, Alexandre Morrot, C Kurts, DP Dialynas, F Ossendorp, F Zavala, Fidel Zavala, G Sano, Gen-ichiro Sano, H Bodmer, J Ohara, JA Keene, JA Pedras-Vasconcelos, JD Altman, JM McCune, JM Riberdy, JP Ridge, Julius C.R. Hafalla, KS Schluns, L Peng, LH Carvalho, LR Huang, Luzia H. Carvalho, Maria A. Curotto de Lafaille, MH Kaplan, MM Rodrigues, P Borrow, P Romero, RA Tripp, RD Cardin, RJ Armitage, RM Buller, RP Bucy, SO Andreasen, SP Schoenberger, SR Bennett, T Ohteki, T Schuler, W Allan, WE Paul, WE Seaman, WR Weiss, Y Miyahira, Z Lu   +44 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Immune evasion by TGFβ-induced miR-183 repression of MICA/B expression in human lung tumor cells

OncoImmunology, 2019
Immune escape is a hallmark of cancer. In human lung cancer, we have identified a unique microRNA (miR)-based pathway employed by tumor cells to repress detection by immune cells via the NKG2D-MICA/B receptor-ligand system.
Thu Le Trinh, Wendy M. Kandell, Sarah S. Donatelli, Nhan Tu, Melba M. Tejera, Danielle L. Gilvary, Erika A. Eksioglu, Alexis Burnette, William A. Adams, Jinhong Liu, Jamie K. Teer, Julie Y. Djeu, Domenico Coppola, Sheng Wei   +13 more
doaj   +1 more source

Myeloid conditioning with c-kit-targeted CAR-T cells enables donor stem cell engraftment [PDF]

, 2018
We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising.
Arai, Yasuyuki, Black, Mary A, Choi, Uimook, Corsino, Cristina I, Dinauer, Mary C, Feldman, Steven A, Koontz, Sherry M, Malech, Harry L, Sweeney, Colin L, Tajima, Masaki   +9 more
core   +2 more sources