Results 101 to 110 of about 1,057,642 (298)

FUNCTIONAL AORTIC STIFFNESS:ROLE OF CD4+ T LYMPHOCYTES

Frontiers in Physiology, 2015
The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte ...
Beenish A. Majeed, Lance S. Eberson, Supannikar eTawinwung, Nicolas eLarmonier, Timothy W. Secomb, Douglas F Larson   +5 more
doaj   +1 more source

Membrane Surface Nanostructures and Adhesion Property of T Lymphocytes Exploited by AFM [PDF]

, 2009
The activation of T lymphocytes plays a very important role in T-cell-mediated immune response. Though there are many related literatures, the changes of membrane surface nanostructures and adhesion property of T lymphocytes at different activation ...
Yangzhe Wu, Hongsong Lu, Jiye Cai, Xianhui He, Yi Hu, HongXia Zhao, Xiaoping Wang, X Zhang, G Binnig, Z Wang, SR Jian, HJ Butt, K Waar, SE Cross, WA Lam, P Parot, A Franco-Obregon, EP Wojcikiewicz, X Zhang, X Zhang, WF Heinz, S Strasser, WR Bowen, E Canetta, V Lulevich, EP Wojcikiewicz, W Fritzsche, W Fritzsche, GA Burks, JK Burkhardt, S Dadsetan, S Feske, PA Negulescu, L Xu   +33 more
core   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Allorecognition by T lymphocytes and allograft rejection

Frontiers in Immunology, 2016
Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the adaptive inflammatory immune response leading to the rejection of allogeneic transplants.
Gilles Benichou, Jose Marino, Joshua Paster   +2 more
doaj   +1 more source

Separation of lymphocytes by electrophoresis under terrestrial conditions and at zero gravity, phase 3 [PDF]

Electrophoretic mobilities (EPM) of peripheral lymphocytes were studied from normal subjects, chronic hemodialysis patients and kidney transplant recipients.
Cheigh, J. S., Novogrodsky, A., Rubin, A. L., Seaman, G. V. F., Stenzel, K. H.   +4 more
core   +1 more source

T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation [PDF]

, 1992
Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading to tissue damage ...
Eisenburg, Josef, Hoffmann, Robert M., Jung, Maria C., Messer, Gerald, Möller, Achim, Paumgartner, Gustav, Riethmüller, Gert, Spengler, Ulrich, Weiss, Elisabeth H., Zachoval, Reinhard   +9 more
core   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Physiological implications of NTBI uptake by T lymphocytes [PDF]

, 2014
In iron overload disorders a significant fraction of the total iron circulates in the plasma as low molecular weight complexes not bound to transferrin, known as non-transferrin-bound iron (NTBI).
Arezes, J., Carlsson, A., Costa, M., Dias, V., Oliveira, S., Pinto, J., Porto, G., Rangel, M., Rikers, Y., Vieira, I., Vos, M.   +10 more
core   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source