Results 141 to 150 of about 1,835 (190)

Increased context-dependent conditioning to amphetamine in mice lacking TAAR1

Pharmacological Research, 2016
Given the recent evidence indicating that amphetamine derivatives may also act as direct agonists of the G protein-coupled trace amine-associated receptor 1 (TAAR1), we hypothesized that TAAR1 could contribute to the reinforcing and addictive properties ...
Lucia Caffino, Ilya Sukhanov, Stefano Espinoza   +2 more
exaly   +7 more sources

TAAR1-dependent effects of apomorphine in mice

International Journal of Neuropsychopharmacology, 2014
G protein-coupled trace amine-associated receptor 1 (TAAR1) is expressed in several brain regions and modulates dopaminergic activity partially by affecting D2 dopamine receptor function. In vitro, the nonselective dopamine agonist apomorphine can activate mouse and rat TAAR1. The aim of the present study was to evaluate whether apomorphine activity at
Marius Hoener, Dmitry Yakovlev, Ilya Sukhanov   +2 more
exaly   +5 more sources

Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence from Preclinical Models and Clinical Studies

International Journal of Molecular Sciences, 2021
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target for neuropsychiatric disorders due to its ability to modulate monoaminergic and glutamatergic neurotransmission.
Grazia Rutigliano, Oliver Howes, Nina Dedic   +2 more
exaly   +3 more sources

Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: Role of D2 dopamine autoreceptors

Neuropharmacology, 2014
Trace Amine-Associated Receptor I (TAAR1) is a G protein-coupled receptor (GPCR) expressed in several mammalian brain areas and activated by "trace amines" (TAs).
Marius Hoener, Liudmila Mus, Stefano Espinoza   +2 more
exaly   +2 more sources

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Selective TAAR1 agonists induce conditioned taste aversion

Psychopharmacology, 2022
Trace amine-associated receptor 1 (TAAR1) is the best-studied receptor of trace amines, a group of biogenic amines expressed at a relatively low level in the mammalian brain. Growing evidence suggests that TAAR1 plays a critical role in various neuropsychiatric disorders.
Jun-Xu Li, Bernard Johnson, Jian-Feng Liu   +2 more
exaly   +3 more sources

Neuronal Functions and Emerging Pharmacology of TAAR1

2014
Trace amine-associated receptor 1 (TAAR1) is a member of TAAR family of G protein-coupled receptors (GPCRs). The members of this class of receptors discovered in 2001 have been found in some tissues ranging from the central nervous system to the olfactory epithelium and in some peripheral organs.
Espinoza S, Gainetdinov RR
openaire   +3 more sources

The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats

Cellular and Molecular Neurobiology, 2019
Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited.
Irina V. Belozertseva, Ilya Sukhanov, Edwin Zvartau   +2 more
exaly   +3 more sources