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Diisopropylphosphorofluoridate and Tabun: Enzymatic Hydrolysis and Nerve Function
Science, 1971Squid nerve contains an enzyme that hydrolyzes the nerve gas Tabun at about one-tenth the rate it hydrolyzes diisopropylphosphorofluoridate (DFP), and at about one-third to one-fourth the rate it hydrolyzes Sarin and Soman. Tabun is a more potent inhibitor of acetylcholinesterase than is DFP, is both lipid- and water-soluble, and penetrates readily ...
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Synthesis of a New Reactivator (I) of Tabun‐Inhibited Acetylcholinesterase.
ChemInform, 2003Synthesis of a new asymmetric bisquaternary reactivator of tabun-inhibited acetylcholinesterase-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide is described. Reactivation potency of this oxime is compared to the currently used reactivators-pralidoxime, obidoxime and H-oxime HI-6.
Kamil, Kuca +3 more
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Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation
Journal of the American Chemical Society, 2008Human butyrylcholinesterase (hBChE) hydrolyzes or scavenges a wide range of toxic esters, including heroin, cocaine, carbamate pesticides, organophosphorus pesticides, and nerve agents. Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine.
Eugénie, Carletti +11 more
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Capillary column gas chromatography—mass spectrometry of tabun
Journal of Chromatography A, 1985Abstract A simple of munitions grade tabun, known to contain several impurities, was studied by combined capillary column gas chromatography—mass spectrometry under both electron-impact and chemical ionization conditions. Five impurities, three of which were previously unreported in tabun, were identified and characterized based on their mass ...
P.A. D'Agostino +3 more
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The Tabun Cave and Paleolithic Man in the Levant
Science, 1982Recent excavations at the deeply stratified Late Pleistocene cave site of Tabun on Mount Carmel have yielded a long sequence of Middle and Lower Paleolithic industries and associated geological and environmental evidence that has important implications for the understanding of man's cultural and biological development in that period.
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A Reassessment of the Tabun C2 Mandible
2005As recently as just over a decade ago, a reasonable case could be made that modern humans initially appeared throughout the Old World, essentially contemporaneously, between 40 ka and 30 ka (e.g., Wolpoff 1980; Smith 1985). Objections to such an interpretation were numerous and grounded in various lines of evidence (e.g., Howells 1976; Stringer 1978 ...
Rolf M. Quam, Fred H. Smith
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STUDIES ON THE ENZYMATIC HYDROLYSIS OF SARIN AND TABUN
Canadian Journal of Biochemistry and Physiology, 1958The enzymes which hydrolyze isopropyl methylphosphonofluoridate (sarin) and ethyl N, N-dimethylphosphoramidocyanidate (tabun) have been studied. Michaelis–Menten constants and activation energies have been estimated and enzyme stability has been studied. The distribution of the enzymes in mammalian tissues has been examined.
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Oxime-assisted reactivation of tabun-phosphorylated acetylcholinesterase
2006The threat of misuse of highly toxic organophosphorus nerve agent, such as tabun, calls for urgent development of an effective treatment. The basic mechanism of tabun action is the obstruction of cholinergic nerve transmission by inhibiting acetylcholinesterase (AChE ; EC 3.1.1.7) and it can lead to death in just a few minutes.
Katalinić, Maja +3 more
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