Results 231 to 240 of about 3,249 (289)

Toxicokinetics of Tabun Enantiomers in Anaesthetized Swine After Intravenous Tabun Administration

Toxicology Letters, 2010
In the present study, we report the first in vivo toxicokinetic study of tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate). The toxicokinetics of the enantiomers of tabun were investigated in anesthetized swine after intravenous administration of 3xLD(50) (161.4mug/kg) tabun.
Franz Worek
exaly   +3 more sources

STUDIES ON THE ENZYMATIC HYDROLYSIS OF SARIN AND TABUN

Canadian Journal of Biochemistry and Physiology, 1958
The enzymes which hydrolyze isopropyl methylphosphonofluoridate (sarin) and ethyl N, N-dimethylphosphoramidocyanidate (tabun) have been studied. Michaelis–Menten constants and activation energies have been estimated and enzyme stability has been studied. The distribution of the enzymes in mammalian tissues has been examined.
Peter A. Adie
openaire   +3 more sources

INHIBITION OF THE ESTERATIC ACTIVITY OF THROMBIN BY SARIN AND TABUN

Canadian Journal of Biochemistry and Physiology, 1959
Isopropyl methylphosphonofluoridate (sarin) and ethyl N,N-dimethylphosphoramidocyanidate (tabun) have been found to inhibit the esteratic activity of thrombin towards the substrate p-toluenesulphonyl-L-arginine methyl ester. The rate of inhibition is markedly dependent on pH and is greatest in alkaline solutions.
J, SHUSTER, J F, SCAIFE, G A, GRANT
openaire   +3 more sources

THE INDUCTION OF METHEMOGLOBINEMIA AS AN ADJUNCT TO THERAPY FOR TABUN POISONING

Canadian Journal of Biochemistry and Physiology, 1960
The protective and therapeutic effectiveness of p-aminopropiophenone (PAPP) against tabun poisoning in the rat has been examined. The relationship between dosage of PAPP and percentage of methaemoglobin in the blood of the rat has been determined.Treatment of rats with PAPP both alone and in conjunction with atropine gave no evidence of protection ...
I W, COLEMAN, P E, LITTLE, G A, GRANT
openaire   +3 more sources

Effective Bisquaternary Reactivators of Tabun-Inhibited AChE

Journal of Applied Toxicology, 2005
AbstractTwo cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun‐inhibited acetylcholinesterase of the rat brain was tested in vitro. Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime and HI‐6) were practically without reactivation potency.
Kamil Kuča, Daniel Jun, Kamil Musílek
exaly   +3 more sources

Effect of Pyridostigmine Pretreatment on Cardiorespiratory Function in Tabun Poisoning

Human and Experimental Toxicology, 1995
1 The effect of pyridostigmine on cardiorespiratory func tion after oxime+atropine injection was investigated in tabun poisoned guinea-pigs and without tabun poisoning. 2 The trachea, a carotid artery and jugular vein were can nulated in female urethane-anaesthetised Pirbright white guinea-pigs.
Franz Worek, Ladislaus Szinicz
exaly   +3 more sources

Direct Reaction of Oximes With Sarin, Soman, or Tabun in Vitro

Archives of Toxicology, 1997
The direct reaction of seven pyridinium oximes with the nerve agents sarin, soman, and tabun was followed by a spectrophotometric method. The half-lives (t1/2) of the oximes, the first- and second-order rate constants (k1, k2), and the maximal reaction velocity (vmax) were calculated according to changes in the absorbance of the zwitterion (betaine ...
L Szinicz
exaly   +3 more sources