Results 251 to 260 of about 9,981 (300)

Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration

Toxicology Letters, 2010
In the present study, we report the first in vivo toxicokinetic study of tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate). The toxicokinetics of the enantiomers of tabun were investigated in anesthetized swine after intravenous administration of 3xLD(50) (161.4mug/kg) tabun.
O, Tenberken, J, Mikler, I, Hill, K, Weatherby, H, Thiermann, F, Worek, G, Reiter   +6 more
exaly   +3 more sources

Effective bisquaternary reactivators of tabun-inhibited AChE

Journal of Applied Toxicology, 2005
AbstractTwo cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun‐inhibited acetylcholinesterase of the rat brain was tested in vitro. Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime and HI‐6) were practically without reactivation potency.
Kamil Kuca, Kamil Musilek, Daniel Jun
exaly   +3 more sources

The Tabun Cave and Paleolithic Man in the Levant

Science, 1982
Recent excavations at the deeply stratified Late Pleistocene cave site of Tabun on Mount Carmel have yielded a long sequence of Middle and Lower Paleolithic industries and associated geological and environmental evidence that has important implications for the understanding of man's cultural and biological development in that period.
exaly   +3 more sources

Diisopropylphosphorofluoridate and Tabun: Enzymatic Hydrolysis and Nerve Function

Science, 1971
Squid nerve contains an enzyme that hydrolyzes the nerve gas Tabun at about one-tenth the rate it hydrolyzes diisopropylphosphorofluoridate (DFP), and at about one-third to one-fourth the rate it hydrolyzes Sarin and Soman. Tabun is a more potent inhibitor of acetylcholinesterase than is DFP, is both lipid- and water-soluble, and penetrates readily ...
exaly   +3 more sources

Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation

Journal of the American Chemical Society, 2008
Human butyrylcholinesterase (hBChE) hydrolyzes or scavenges a wide range of toxic esters, including heroin, cocaine, carbamate pesticides, organophosphorus pesticides, and nerve agents. Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine.
Fredrik Ekström, Yvain Nicolet, Oksana Lockridge   +2 more
exaly   +3 more sources

Sarin, Soman, Tabun und VX

Notfall & Rettungsmedizin, 2002
Lange Zeit war ein chemischer Kampfmittelangriff ein militarisches Szenario. Spatestens seit der Attacke mit Sarin auf die Tokioter U-Bahn im Jahre 1995 durch den Aum-Shinrikyo-Kult werden zivile Kampfstoffeinsatze in den Szenarien von vielen Katastrophenplanern mit einbezogen.
T. Bey, F. G. Walter
openaire   +1 more source

Novel and selective detection of Tabun mimics

Chem. Commun., 2014
Detection of nerve agent-related molecules based on BODIPY–salicylaldehyde oxime conjugation was studied.
Jang, YJ Jang, Yoon Jeong, Tsay, OG Tsay, Olga G., Murale, DP Murale, Dhiraj P., Jeong, JA Jeong, Jeong A., Segev, A Segev, Aviv, Churchill, DG Churchill, DG   +5 more
openaire   +3 more sources

Toxogonin in Sarin, Soman and Tabun poisoning

Biochemical Pharmacology, 1965
The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase. The protective effect of the oximes has been studied on atropinized mice in experimental Sarin, Soman and Tabun poisoning. Toxogonin is a better reactivator than P2S and comparable to TMB-4. In the presence of 10 mg/kg atropine (i.p.)
E, HEILBRONN, B, TOLAGEN
openaire   +2 more sources

Genotoxicity of the phosphoramidate agent tabun (GA)

Toxicology, 1994
Five mutagenicity tests were performed on Agent GA (Tabun, phosphoramidocyanidic acid, dimethyl-, ethyl ester) as part of a program to demilitarize chemical warfare agents. GA was mutagenic in Salmonella spp. assays with S-9 and it was a direct-acting mutagen to mouse lymphoma cells.
B W, Wilson, T G, Kawakami, N, Cone, J D, Henderson, L S, Rosenblatt, M, Goldman, J C, Dacre   +6 more
openaire   +2 more sources