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Oxime K203: a drug candidate for the treatment of tabun intoxication
Archives of Toxicology, 2018For over 60 years, researchers across the world have sought to deal with poisoning by nerve agents, the most toxic and lethal chemical weapons. To date, there is no efficient causal antidote with sufficient effect. Every trialed compound fails to fulfil one or more criteria (e.g. reactivation potency, broad reactivation profile).
Lukas Gorecki +7 more
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Delayed neuropathy by the organophosphorus nerve agents soman and tabun
Archives of Toxicology, 1984The organophosphorus nerve agents soman and tabun were tested in the hen at doses 120-150 times higher than their acute LD50, as it was assumed that these doses would produce delayed neuropathy. The animals were protected against the acute lethal effect of these agents by pretreatment with atropine, physostigmine, diazepam, and the oxime HI-6 or ...
J L, Willems +2 more
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HI-6 Therapy of Soman and Tabun Poisoning in Primates and Rodents
Archives of Toxicology, 1989Paul M Lundy, M G Hamilton, P M Lundy
exaly