Results 241 to 250 of about 9,981 (300)

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Efficient Decontamination of Organophosphate-Based Pesticides and Nerve Agent Simulants Mediated by N‑Containing Nucleophiles. [PDF]

ACS Omega
Darkwah EK, Aryal P, Todeti S, Kenik J, Insall S, Reddy VP, Sotiriou-Leventis C.   +6 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Neandertal Cold Adaptation: Technological, Anatomical, and Physiological Responses to Cold Stress in One of Our Closest Fossil Relatives. [PDF]

Am J Hum Biol
Holliday TW, Ocobock C, Cowgill LW, Maddux SD.   +3 more
europepmc   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity. [PDF]

JACS Au
Jacquet P, Billot R, Shimon A, Hoekstra N, Bergonzi C, Jenks A, Chabrière E, Daudé D, Elias MH.   +8 more
europepmc   +1 more source

Climate change in Europe between 90 and 50 kyr BP and Neanderthal territorial habitability. [PDF]

PLoS One
Degioanni A, Cabut S, Condemi S, Smith RS.   +3 more
europepmc   +1 more source

Ardipithecus ramidus ankle provides evidence for African ape-like vertical climbing in the earliest hominins. [PDF]

Commun Biol
Prang TC, Tocheri MW, Patel BA, Williams SA, Orr CM.   +4 more
europepmc   +1 more source

A Late Pleistocene archaic human tooth from Gua Dagang (Trader's Cave), Niah national park, Sarawak (Malaysia). [PDF]

PLoS One
Curnoe D, Sauffi MS, Goh HM, Sun XF, Peiris R.   +4 more
europepmc   +1 more source

Genetic resources of tabun horses of Yakutia

, 2019
openaire   +1 more source