Results 41 to 50 of about 9,981 (300)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecules, 2007 Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used
Jan Marek +6 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Nerve agents: A clear and present danger to mankind [PDF]
Scripta Medica, 2019 This editorial is written on the occasion of the 25th anniversary of the infamous sarin and VX terrorist attacks in Japan, in order to increase the awareness of the potential terrorist use of nerve agents and to urge the preparedness to cope with its ...
Stojiljković Miloš P.
doaj
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Itsemurhatartunnan taikauskosta: The Moth Diaries (2011) ja 13 Reasons Why (2017)
Tahiti, 2018 Artikkeli käsittelee kahden itsemurhaa kuvaavan populaarikulttuurin tapausesimerkin, The Moth Diaries -elokuvan ja 13 Reasons Why -sarjan, ja tabun käsitteen välityksellä itsemurhaan liitettyä tartunnan pelkoa ja tämän pelon ilmenemistä viihteen ja ...
Heidi S. Kosonen
doaj +1 more source
The Balance Sheet: The Costs and the Gains of the Bombing Campaign [PDF]
, 2012 Critics of the bomber offensive frequently argue that the material and human cost of the campaign far overshadowed the gains, and that the resources dedicated to it could have been more effectively utilized elsewhere.
Bashow, David L.
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Penerapan Sanksi terhadap Pelanggaran Pptkis dalam PRA Penempatan Tki di Luar Negeri [PDF]
, 2007 Act 39 of 2004 concerning Placement and Protection of Indonesian Labor in Foreign Country has detf!rmined and regulated sanction that can be deliveredfor violation by Private Indonesian Labor Placement Agency (PPTKlS) in worker pre-placement inforeign ...
Hernawan, A. (Ari), S, S. (Supriyadi)
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source