Results 31 to 40 of about 3,172 (283)

Counteracting poisoning with chemical warfare nerve agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj   +1 more source

Tabun Unit I Flake Models

, 2011
Dataset consists of one ZIP archive containing 91 virtual flake models, each represented by one OBJ file with an accompanying MTL file, for 182 total files.
Hunstiger, Matthew D
core   +1 more source

Tabun Unit IX Flake Models

, 2011
Dataset consists of one ZIP archive containing 279 virtual flake models, each represented by one OBJ file with an accompanying MTL file, for 558 total files.
Hunstiger, Matthew D
core   +1 more source

Energetics of Ortho-7 (oxime drug) translocation through the active-site gorge of tabun conjugated acetylcholinesterase. [PDF]

PLoS ONE, 2012
Oxime drugs translocate through the 20 Å active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds' (such as tabun) conjugation.
Vivek Sinha, Bishwajit Ganguly, Tusar Bandyopadhyay   +2 more
doaj   +1 more source

The overlapping between the crystal structure of tabun-inhibited AChE with Ortho-7 and the docked conformation of Ortho-7 with tabun-inhibited AChE.

, 2013
(Yellow = crystal structure of tabun-inhibited AChE with Ortho-7 and Magenta = docked conformation of tabun-inhibited AChE with Ortho-7).
Aastha Jain (491658), Nellore Bhanu Chandar (491656), Rabindranath Lo (491655), Manoj K. Kesharwani (491657), Bishwajit Ganguly (151701)   +4 more
core   +1 more source

Chemical Weapons: History of the Study of Organophosphorus Toxic Agents Abroad

Вестник войск РХБ защиты, 2023
Organophosphorus compounds occupy a unique positon among all chemical warfare agents (CWA's). Since the 1930-s their high toxicity, wide range of physical-chemical properties and complex action attracted close attention of foreign military experts.
I. A. Nelga, I. V. Medvetsky, A. V. Zlobin, S. V. Tretyakov, A. V. Sherstyuk, I. V. Kostyuchenko   +5 more
doaj   +1 more source

Observations on Pharmacology of the Anticholinesterases Sarin and Tabun

Experimental Biology and Medicine, 1954
SummaryThe phosphate esters sarin and tabun, potent anticholinesterase compounds, exert profound effects on the respiration, circulation, central nervous system and gastrointestinal tract of experimental animals.
S, KROP, A M, KUNKEL
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze

Acta Medica, 2006
In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals.
Gabriela Kunešová, Jiří Kassa
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source