Results 11 to 20 of about 3,249 (289)

A Comparison of the Potency of Newly Developed Oximes (K347, K628) and Currently Available Oximes (Obidoxime, HI-6) to Counteract Acute Neurotoxic Effects of Tabun in Rats

Acta Medica, 2010
The ability of newly developed oximes (K347, K628) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oximes (obidoxime, HI-6) using a functional observational battery.
Jiří Kassa, Jana Žďárová Karasová, Sandra Tesařová, Kamil Musílek, Kamil Kuča   +4 more
doaj   +2 more sources

The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats

Acta Medica, 2016
Aim: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats.
Jiří Kassa, Jana Hatlapatková, Jana Žďárová Karasová   +2 more
doaj   +2 more sources

The Influence of the Time of Antidotal Treatment Administration on the Potency of Newly Developed Oximes to Counteract Acute Toxic Effects of Tabun in Mice

Acta Medica, 2005
1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and newly developed oxime (K027 or K048) on its effectiveness to eliminate tabun-induced lethal toxic effects was studied in mice. 2.
Jiří Kassa
doaj   +2 more sources

The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice

Acta Medica, 2004
Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj   +2 more sources

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203

Molecules, 2017
The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and ...
Jiri Kassa, Jan Misik, Jana Hatlapatkova, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger, Jaroslav Pejchal   +6 more
doaj   +2 more sources

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

BMC Pharmacology and Toxicology, 2018
Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes.
Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho   +12 more
doaj   +2 more sources

The Influence of Anticholinergic Drug and Oxime Selection on the Effectiveness of Antidotal Treatment Against Tabun-Induced Poisoning in Mice

Acta Medica, 2002
1. The influence of oximes (pralidoxime, obidoxime, HI-6) and anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) on the effectiveness of antidotal treatment to eliminate tabun-induced lethal effects was studied in mice. 2.
Jiří Kassa
doaj   +2 more sources

Effect of Methoxime Combined with Anticholinergic, Anticonvulsant or Anti-HCN Drugs in Tabun-Poisoned Mice

Acta Medica, 2003
The effect of methoxime combined with a) atropine, b) benactyzine, c) atropine and natrium thiosulphate, d) atropine and diazepam on antidotal treatment effectiveness was studied in tabun-poisoned mice.
Lucie Ševelová, Josef Vachek
doaj   +2 more sources

Energetics of Ortho-7 (oxime drug) translocation through the active-site gorge of tabun conjugated acetylcholinesterase. [PDF]

PLoS ONE, 2012
Oxime drugs translocate through the 20 Å active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds' (such as tabun) conjugation.
Vivek Sinha, Bishwajit Ganguly, Tusar Bandyopadhyay   +2 more
doaj   +2 more sources

Ethnomathematics on Dayak Tabun Traditional Tools for School Mathematics Learning [PDF]

International Journal of Trends in Mathematics Education Research, 2019
The purpose of this study was to describe ethnomathematics on Dayak Tabun traditional tools in school mathematics learning. This study uses a qualitative approach, with descriptive research methods.
Hartono Hartono, Marhadi Saputro
doaj   +2 more sources