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Tacrolimus in Renal Transplantation [PDF]
, 2008 Tacrolimus (Prograf-FK506) has been used since 1989 as a primary immunosuppressive agent in adult and pediatric renal transplant recipients at our institution.1,2 This report will summarize our experience with it over the past six years and will demonstrate its overall efficacy and superiority.
Shapiro, R +15 more
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Tacrolimus in membranous nephropathy [PDF]
Kidney International, 2008 To the Editor: In a recent issue of the Journal, Praga et al.1 reported their experience with tacrolimus monotherapy in patients with idiopathic membranous nephropathy. The authors concluded that tacrolimus was a very useful therapeutic option. This conclusion was based on the findings of a higher remission rate and a reduced risk of deterioration of ...
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Tacrolimus as Antifungal Agent
Acta Chimica Slovenica, 2019 Tacrolimus (FK506) is an immunosuppressant drug widely used to avoid organ rejection in transplant patients. It has a profound influence on the cellular stress response by interfering with the calmodulin-calcineurin signaling pathway. In this context FK506 also became a valuable antifungal drug in medical care. Here it is shown in vitro that tacrolimus
Fatuma Meyer +4 more
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A new immunosuppressant: tacrolimus [PDF]
Postgraduate Medical Journal, 1996 Summary Tacrolimus is the new name for the Japanese immunosuppressant drug FK506. It blocks interleukin 2 transcription thereby inhibiting the CD4 Th-1 lymphocyte response to foreign antigens. It also selectively inhibits cytokine secretion of IL3, IL4 and interferon-gamma. It is metabolised by the cytochrome P-450 enzyme system.
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An interaction between tacrolimus and pristinamycin resulting in an elevated tacrolimus level [PDF]
Clinical Kidney Journal, 2011 We report a case of interaction between tacrolimus and pristinamycin. A 62-year-old man, Mr TM, presented with a 2-day history of increased pain and left knee swelling after a twisting injury. This occurred 1 year after renal transplantation for end-stage kidney disease from membranous glomerulonephropathy, complicated by an episode of acute rejection ...
Tehan, JV, Tan, SJ, Gregg, W, Dwyer, K
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Role of Diltiazem on Tacrolimus Pharmacokinetics in Tacrolimus‐Induced Nephrotoxic Rats [PDF]
Pharmacology & Toxicology, 1999 Abstract:The effects of diltiazem on tacrolimus pharmacokinetics during tacrolimus‐induced nephrotoxicity were studied. In normal rats, co‐administration of diltiazem significantly increased AUC0–∞of tacrolimus and reduced total body clearance, Cltot, after intravenous and oral administration.
K. Ito +3 more
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Granuloma faciale treatment with tacrolimus [PDF]
Dermatology Online Journal, 2016 We present a 40-year-old woman with a one-year history of a solitary and asymptomatic facial lesion. On physical examination a slightly infiltrated, smooth red to brown nodule was seen at the left malar region. A biopsy established the diagnosis of granuloma faciale. After two-months therapy with topical tacrolimus 0,1%, nodule was resolved.
Santos-Alarcon, Sergio +3 more
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Yonsei Medical Journal, 2004 Modified Release (MR) tacrolimus is an extended release formulation of tacrolimus (Prograf) administered once daily in the morning. In healthy volunteers, the MR tacrolimus formulation given qd AM and Prograf administered twice daily (bid) have a similar exposure (AUC) and trough levels (Cmin), with a reduced peak level (Cmax).
William E. Fitzsimmons, M. Roy First
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Combined microneedling with tacrolimus vs tacrolimus monotherapy for vitiligo treatment
Journal of Dermatological Treatment, 2020 Miconeedling has been used to augment the transdermal drug delivery. Combination modalities may accelerate and improve the repigmentation in vitiligo.To determine the efficacy and tolerability of combined microneedling with tacrolimus vs tacrolimus 0.1% ointment for the treatment of vitiligo.Forty-eight patients with vitiligo were randomized into two ...
Waleed Albalate +2 more
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Pantoprazole and cyclosporine or tacrolimus [PDF]
Alimentary Pharmacology & Therapeutics, 2001 Schwrer, H. +3 more
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