Results 21 to 30 of about 157,199 (404)

Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus

BMC Gastroenterology, 2021
Background Intravenous corticosteroid is the mainstay for managing acute severe ulcerative colitis, but one-third of patients do not respond to intravenous corticosteroid.
Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto   +10 more
doaj   +1 more source

Clinical association between tacrolimus intra-patient variability and liver transplantation outcomes in patients with and without hepatocellular carcinoma

Scientific Reports, 2022
Tacrolimus is the mainstay of immunosuppression in liver transplantation to prevent rejection. However, the clinical use of tacrolimus is complicated by its narrow therapeutic window and significant intra-patient variability (IPV). High tacrolimus IPV is
Hyun Jeong Kim, Juhan Lee, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim   +4 more
doaj   +1 more source

Tacrolimus analysis: A comparison of different methods and matrices [PDF]

, 1995
We determined the trough blood and plasma concentrations of tacrolimus from the day of transplantation through 30 days posttransplantation in four liver and four kidney transplant patients by three different methods.
Chao, J, Fung, J, Lever, W, McKaveney, T, Starzl, T, Venkataramanan, R, Warty, V, Zuckerman, S   +7 more
core   +1 more source

Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report

Therapeutic Drug Monitoring, 2019
: Ten years ago, a consensus report on the optimization of tacrolimus was published in this journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicity (IATDMCT)
M. Brunet, T. van Gelder, A. Åsberg, V. Haufroid, D. Hesselink, L. Langman, F. Lemaitre, P. Marquet, C. Seger, M. Shipkova, A. Vinks, P. Wallemacq, E. Wieland, J. Woillard, M. Barten, K. Budde, H. Colom, M. Dieterlen, L. Elens, K. Johnson-Davis, P. Kunicki, I. Macphee, S. Masuda, B. Mathew, O. Millán, T. Mizuno, D. Moes, C. Monchaud, Ofelia Noceti, T. Pawiński, N. Picard, R. V. van Schaik, C. Sommerer, N. T. Vethe, B. D. de Winter, U. Christians, S. Bergan   +36 more
semanticscholar   +1 more source

Butyric acid normalizes hyperglycemia caused by the tacrolimus‐induced gut microbiota

American Journal of Transplantation, 2020
Approximately 33.6% of nondiabetic solid organ transplant recipients who received tacrolimus developed hyperglycemia. Whether the tacrolimus‐induced gut microbiota is involved in the regulation of hyperglycemia has not been reported.
W. Jiao, Zijian Zhang, Yue Xu, Lian Gong, Weixun Zhang, Hao Tang, S. Zeng, Qiang Zhang, Zhaoli Sun, Ling Liu, Xiaopeng Hu   +10 more
semanticscholar   +1 more source

Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels [PDF]

, 2019
Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin.
Blume-Peytavi, Ulrike, Calderón, Marcelo, Giulbudagian, Michael, Kleuser, Burkhard, Rancan, Fiorenza, Schumacher, Fabian, Stanko, Jessica Isolde, Vogt, Annika, Volkmann, Hildburg   +8 more
core   +3 more sources

Tacrolimus Concentration Is Effectively Predicted Using Combined Clinical and Genetic Factors in the Perioperative Period of Kidney Transplantation and Associated with Acute Rejection

Journal of Immunology Research, 2022
Background. Tacrolimus has unpredictable pharmacokinetic (PK) characteristics, which are partially attributed to CYP3A5 polymorphism. The potential effects of clinical factors in the postoperative period of transplantation on tacrolimus PK and those of ...
Fang Cheng, Qiang Li, Zheng Cui, Zhendi Wang, Fang Zeng, Yu Zhang   +5 more
doaj   +1 more source

Efficacy and safety of a switch from twice-daily tacrolimus to once-daily generic tacrolimus in stable liver transplant patients

Korean Journal of Transplantation, 2021
Background : Once-daily tacrolimus reduces non-compliance relative to twice-daily tacrolimus. However, little is known about the safety and efficacy of conversion from twice-daily tacrolimus to generic once-daily tacrolimus in liver transplantation (LT).
Jong Man Kim, Pyoung-Jae Park, Geun Hong, Dong Jin Joo, Kwan Woo Kim, Je Ho Ryu, Young Seok Han, Jai Young Cho, Gi-Won Song, Bong-Wan Kim, Dong-Sik Kim, Seong Hoon Kim, Sang Tae Choi, Young Kyoung You, Kyung-Suk Suh, Yang-Won Na, Koo Jeong Kang, Jae-Won Joh   +17 more
doaj   +1 more source

Tacrolimus intrapatient variability in solid organ transplantation: A multiorgan perspective

Pharmacotherapy, 2020
Tacrolimus therapy in solid organ transplant (SOT) recipients is challenging due to its narrow therapeutic window and pharmacokinetic variability both between patients and within a single patient.
Lauren Schumacher, A. Leino, Jeong M. Park   +2 more
semanticscholar   +1 more source

Protocol TOP-Study (tacrolimus organ perfusion): a prospective randomized multicenter trial to reduce ischemia reperfusion injury in transplantation of marginal liver grafts with an "ex vivo" tacrolimus perfusion [PDF]

, 2013
Background: Critical organ shortage results in the utilization of extended donor criteria (EDC) liver grafts. These marginal liver grafts are prone to increased ischemia reperfusion injury (IRI) which may contribute to deteriorated graft function and ...
Angele, Martin Kurt, Eder, Michael, Heise, Michael, Jauch, Karl-Walter, Nadalin, Silvio, Pascher, Andreas, Pratschke, Sebastian, Schemmer, Peter, Scherer, Marcus N., Ulrich, Frank, Wolters, Heiner, Wöhling, Dirk   +11 more
core   +1 more source