Results 51 to 60 of about 157,199 (404)

Population Pharmacokinetic Study of Tacrolimus in Pediatric Patients with Primary Nephrotic Syndrome: A Comparison of Linear and Nonlinear Michaelis Menten Pharmacokinetic Model [PDF]

Eur J Pharm Sci. 2020 Feb 15;143:105199, 2019
Background Little is known about the population pharmacokinetics (PPK) of tacrolimus (TAC) in pediatric primary nephrotic syndrome (PNS). This study aimed to compare the predictive performance between nonlinear and linear PK models and investigate the significant factors of TAC PK characteristics in pediatric PNS.
arxiv   +1 more source

Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn's Disease [PDF]

, 2013
Peer reviewedPublisher ...
El-Omar, Emad, Keenan, Ronald A, Ormerod, Anthony D, Rice, Shantini A, Woo, Pick N   +4 more
core   +2 more sources

Predicting tacrolimus exposure in kidney transplanted patients using machine learning [PDF]

arXiv, 2022
Tacrolimus is one of the cornerstone immunosuppressive drugs in most transplantation centers worldwide following solid organ transplantation. Therapeutic drug monitoring of tacrolimus is necessary in order to avoid rejection of the transplanted organ or severe side effects.
arxiv  

A case report: acute pancreatitis associated with tacrolimus in kidney transplantation

BMC Nephrology, 2019
Background Tacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades.
Junnan Xu, Liang Xu, Xing Wei, Xiang Li, Ming Cai   +4 more
doaj   +1 more source

Comparative Study of the Cellular Pharmacodynamics of Tacrolimus in Renal Transplant Recipients Treated with and without Basiliximab

Cell Transplantation, 2012
Basiliximab is a recently developed immunosuppressive agent for the prevention of acute allograft rejection in renal transplant recipients. The combination use of basiliximab and a calcineurin inhibitor was suggested to be more effective in comparison to
Kentaro Sugiyama Ph.D., Kazuya Isogai, Satoshi Horisawa, Akira Toyama, Hiroshi Satoh, Kazuhide Saito, Yuki Nakagawa, Masayuki Tasaki, Kota Takahashi, Toshihiko Hirano   +9 more
doaj   +1 more source

Variability of Tacrolimus Trough Concentration in Liver Transplant Patients: Which Role of Inflammation?

Pharmaceutics, 2021
Tacrolimus presents high intra and inter-individual variability in its blood trough concentration (Cmin). Knowledge of the factors that are involved in tacrolimus Cmin variability is thus clinically important to prevent or limit it.
Anaelle Chavant, Xavier Fonrose, Elodie Gautier-Veyret, Marie Noelle Hilleret, Matthieu Roustit, Francoise Stanke-Labesque   +5 more
doaj   +1 more source

Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development.

Journal of the American Society of Nephrology, 2017
Despite more than two decades of use, the optimal maintenance dose of tacrolimus for kidney transplant recipients is unknown. We hypothesized that HLA class II de novo donor-specific antibody (dnDSA) development correlates with tacrolimus trough levels ...
C. Wiebe, D. Rush, T. Nevins, P. Birk, T. Blydt-Hansen, I. Gibson, A. Goldberg, J. Ho, M. Karpinski, Denise Pochinco, Atul Sharma, L. Storsley, A. Matas, P. Nickerson   +13 more
semanticscholar   +1 more source

Alemtuzumab induction and tacrolimus monotherapy in pancreas transplantation: One- and two-year outcomes [PDF]

, 2006
BACKGROUND. Alemtuzumab (Campath-1H) induction with tacrolimus monotherapy has been shown to provide effective immunosuppression for kidney, liver, lung, and small bowel transplantation.
Abu-Elmagd, Akhtar Khan, Amadeo Marcos, Amit Basu, Calne, Ciano, Deanna Blisard, Flechner, Gruessner, Hale, Henkie P. Tan, John J. Fung, Kaufmann, Kirk, Knechtle, Knechtle, Kusum Tom, Marcos, Marcos, McCurry, Ngoc L. Thai, Ron Shapiro, Shapiro, Shapiro, Starzl, Starzl, Starzl, Starzl, Stuart, Thai, Thomas E. Starzl, Tryphonopoulos, Tzakis, Watson   +33 more
core   +1 more source

A robust kernel machine regression towards biomarker selection in multi-omics datasets of osteoporosis for drug discovery [PDF]

arXiv, 2022
Many statistical machine approaches could ultimately highlight novel features of the etiology of complex diseases by analyzing multi-omics data. However, they are sensitive to some deviations in distribution when the observed samples are potentially contaminated with adversarial corrupted outliers (e.g., a fictional data distribution).
arxiv  

Efficacy of Rituximab vs Tacrolimus in Pediatric Corticosteroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial

JAMA pediatrics, 2018
Importance Calcineurin inhibitors are an established first-line corticosteroid-sparing therapy for patients with corticosteroid-dependent nephrotic syndrome (CDNS), whereas B-lymphocyte–depleting therapy is mostly used as a rescue for calcineurin ...
B. Basu, A. Sander, Birendranath Roy, S. Preussler, Shilpita Barua, T. Mahapatra, F. Schaefer   +6 more
semanticscholar   +1 more source