Results 61 to 70 of about 157,199 (404)

A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients

British Journal of Clinical Pharmacology, 2019
The aims of this study were to describe the pharmacokinetics of tacrolimus immediately after kidney transplantation, and to develop a clinical tool for selecting the best starting dose for each patient.
L. Andrews, D. Hesselink, R. H. Schaik, T. Gelder, J. W. Fijter, N. Lloberas, L. Elens, D. Moes, B. D. Winter   +8 more
semanticscholar   +1 more source

Automated processing of whole blood samples for the determination of immunosuppressants by liquid chromatography tandem-mass spectrometry [PDF]

, 2006
Background: Liquid chromatography tandem-mass spectrometry (LC-MS/MS) is an efficient technology for routine determination of immunosuppressants in whole blood; however, time-consuming manual sample preparation remains a significant limitation of this ...
Spöhrer, Ute, Vogeser, Michael
core   +1 more source

The Association of Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function

Transplantation Direct, 2023
Background. Calcineurin inhibitors are inherent vasoconstrictors. Cerebral vasoconstriction can reduce cerebral blood flow (CBF), and negatively impact cerebrovascular response (CVR) to exercise, and cognitive function.
Irisa Mahaparn, MD, Rebecca J. Lepping, PhD, Robert N. Montgomery, PhD, Rishav Mukherjee, MSc, Sandra A. Billinger, PhD, William M. Brooks, PhD, Aditi Gupta, MD   +6 more
doaj   +1 more source

Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites

Drug Metabolism And Disposition, 2018
Tacrolimus exhibits low and variable drug exposure after oral dosing, but the contributing factors remain unclear. Based on our recent report showing a positive correlation between fecal abundance of Faecalibacterium prausnitzii and oral tacrolimus dose ...
Yukuang Guo, C. Crnkovic, Kyoungjae Won, Xiaotong Yang, J. Lee, J. Orjala, Hyunwoo Lee, Hyunyoung Jeong   +7 more
semanticscholar   +1 more source

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John, Caitlyn Dang, Nidhi Reddy, Calvin Chao, Karen J. Ho, Bin Jiang   +5 more
wiley   +1 more source

Alemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation [PDF]

, 2007
We employed antibody pre-conditioning with alemtuzumab and posttransplant immunosuppression with low-dose tacrolimus monotherapy in 26 consecutive pediatric kidney transplant recipients between January 2004 and December 2005. Mean recipient age was 10.7 ±
Basu, A, Ellis, D, Erkan, E, Gray, EA, Grosso, MJ, James, G, Kayler, LK, Marcos, A, McFeaters, CG, Moritz, ML, Shapiro, R, Starzl, TE, Tan, HP, Vats, AN, Zeevi, A   +14 more
core   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Population pharmacokinetics and dosing regimen optimization of tacrolimus in Chinese lung transplant recipients [PDF]

arXiv, 2020
We aimed to develop a population pharmacokinetic model of tacrolimus in Chinese lung transplant recipients, and propose model based dosing regimens for individualized treatment. We obtained 807 tacrolimus whole blood concentrations from 52 lung transplant patients and genotyped CYP3A5*3. Population pharmacokinetic analysis was performed using nonlinear
arxiv  

A Low Tacrolimus Concentration/Dose Ratio Increases the Risk for the Development of Acute Calcineurin Inhibitor-Induced Nephrotoxicity

Journal of Clinical Medicine, 2019
Fast tacrolimus metabolism is linked to inferior outcomes such as rejection and lower renal function after kidney transplantation. Renal calcineurin-inhibitor toxicity is a common adverse effect of tacrolimus therapy.
G. Thölking, Katharina Schütte-Nütgen, J. Schmitz, A. Rovas, Maximilian Dahmen, Joachim Bautz, U. Jehn, H. Pavenstädt, B. Heitplatz, V. van Marck, B. Suwelack, S. Reuter   +11 more
semanticscholar   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source